Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers

Wimalasiri, V W; Dunuweera, S. P.; Dunuweera, Asiri N.; Rajapakse, R.M.G.

doi:10.1155/2021/6657482

Cited by 9 publications

(3 citation statements)

References 49 publications

(51 reference statements)

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“…According to previous research [15], the structure of extracted keratin is semi-crystalline to amorphous.…”

Section: Resultsmentioning

confidence: 93%

Synthesis and characterization of proton conducting membranes based on human nail keratin and sulfonated polysulfone

Hardiyanti,

Gustian,

Banon

et al. 2023

J. Phys.: Conf. Ser.

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Synthesis and characterization of proton conducting membranes based on human nail keratin and sulfonated polysulfone has been carried out. This research was conducted to make a proton conducting membrane based on acid-base pairs. In this study, human nail was dissolved using NaOH solvent. Through a neutralization process using glacial acetic acid, then evaporation of the solution was carried out to obtain human nail keratin. Sulfonated polysulfone composite membrane-human nail keratin was prepared in mass ratio of 3.5/0.5; 3.3/0.7; 3/1. Composite membranes were characterized by functional group analysis, XRD (X-Ray Diffraction), cation exchange capacity, degree of swelling and proton conductivity. Functional group analysis of sulfonated polysulfone-human nail keratin composite membranes showed interactions at peaks of 3000-3500 cm−1. The composite membrane has the highest cation exchange capacity, which is 2.02 meq/g on the composite membrane variation of 3/1. The greatest degree of swelling in the variation of 3/1 was 33.23%. The highest proton conductivity in the mass variation of 3/1 is 4.87 x 10−5 S/cm. The results of XRD analysis showed that the composite membrane synthesized by human nail keratin and sulfonated polysulfone had semicrystalline properties.

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“…According to previous research [15], the structure of extracted keratin is semi-crystalline to amorphous.…”

Section: Resultsmentioning

confidence: 93%

Synthesis and characterization of proton conducting membranes based on human nail keratin and sulfonated polysulfone

Hardiyanti,

Gustian,

Banon

et al. 2023

J. Phys.: Conf. Ser.

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“…According to the Noyes-Whitney equation, this greatly increases the surface area of the drugs and thus its dissolution. To achieve a controlled or sustained release formulation, the dynamics of drug release could be changed at each of these steps by slightly altering the composition of the nanoemulsion [7].…”

Section: Introductionmentioning

confidence: 99%

Production, Characterization, and In Vitro and In Vivo Studies of Nanoemulsions Containing St. John’s Wort Plant Constituents and Their Potential for the Treatment of Depression

et al. 2023

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The current project was designed to prepare an oil-in-water (oil/water) hypericin nanoemulsion using eucalyptus oil for the preparation of an oil phase with chitosan as an emulsion stabilizer. The study might be a novelty in the field of pharmaceutical sciences, especially in the area of formulation development. Tween® 80 (Polysorbate) was used as the nonionic surfactant. The nanoemulsion was prepared by using the homogenization technique, followed by its physicochemical evaluation. The surface morphological studies showed the globular structure has a nano-sized diameter, as confirmed by zeta size analysis. The zeta potential analysis confirmed a positive surface charge that might be caused by the presence of chitosan in the formulation. The pH was in the range of 5.14 to 6.11, which could also be compatible with the range of nasal pH. The viscosity of the formulations was found to be affected by the concentration of chitosan (F1-11.61 to F4-49.28). The drug release studies showed that the presence of chitosan greatly influenced the drug release, as it was noticed that formulations having an elevated concentration of chitosan release lesser amounts of the drug. The persistent stress in the mouse model caused a variety of depressive- and anxiety-like behaviors that can be counteracted by chemicals isolated from plants, such as sulforaphane and tea polyphenols. In the behavioral test and source performance test, hypericin exhibited antidepressant-like effects. The results show that the mice treated for chronic mild stress had a considerably higher preference for sucrose after receiving continuous hypericin for 4 days (p = 0.0001) compared to the animals administered with normal saline (p ≤ 0.0001) as well as the naïve group (p ≤ 0.0001). In conclusion, prepared formulations were found to be stable and can be used as a potential candidate for the treatment of depression.

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“…Docetaxel, an antimitotic medication, and chlorine 6, a photosensitizer, were produced using in-water synthesis ( Gaio et al, 2019 ). Paclitaxel (Taxol), an anticancer medication, has also been encapsulated in keratin particles ( Wimalasiri et al, 2021 ). Such research demonstrates how keratin particles can be loaded with labile medicines ( Perotto et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Process optimization, antioxidant, antibacterial, and drug adjuvant properties of bioactive keratin microparticles derived from porcupine (Hystrix indica) quills

Majeed,

Farhat,

Ahmad

et al. 2023

PeerJ

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A structural protein called keratin is often employed in the medical industry to create medication carriers. Process improvement, antioxidant, antibacterial, and adjuvant drug studies of synthetic bioactive keratin microparticles made from lipids and keratin derived from porcupine (Hystrix indica) quills are the main objectives of this study. After coating the keratin microparticles with lipids which were obtained from the same porcupine quills, the bioactive keratin microparticles were produced. The response surface technique was applied to optimize the conditions for extraction of the keratin protein and sizing of the keratin microparticles. An infrared spectroscopy was used to analyze the chemical shifts in compositions of keratin microparticles while the optical microscopy was used to measure the size of the keratin microparticles. The results of this work revealed that a yield 27.36 to 42.25% of the keratin protein could be obtained from porcupine quills. The keratin microparticles were sized between 60.65 and 118.87 µm. Through response surface optimization, mercaptoethanol and urea were shown to be the main variables which positively affected the yield and the size of the keratin protein. The lipid stacking on the keratin microparticles’ surface was confirmed by infrared spectroscopy. The 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulphonate) assay confirmed the keratin microparticle’s antioxidant activity of 29.83%. Compared to lipid alone, the antibacterial properties of the keratin microparticles against Escherichia coli—a gram-negative—and Staphylococcus aureus—a gram-positive—bacteria enhanced by up to 55% following the coating of the microparticles with the lipids. The pharmacological action against these bacterial species was further improved by the lipid-loaded erythromycin that was carried on the surface of keratin microparticles. This work has demonstrated the design and uses of the keratin microparticles obtained from porcupine quills for clinical applications.

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Noyes-Whitney Dissolution Model-Based pH-Sensitive Slow Release of Paclitaxel (Taxol) from Human Hair-Derived Keratin Microparticle Carriers

Cited by 9 publications

References 49 publications

Synthesis and characterization of proton conducting membranes based on human nail keratin and sulfonated polysulfone

Synthesis and characterization of proton conducting membranes based on human nail keratin and sulfonated polysulfone

Production, Characterization, and In Vitro and In Vivo Studies of Nanoemulsions Containing St. John’s Wort Plant Constituents and Their Potential for the Treatment of Depression

Process optimization, antioxidant, antibacterial, and drug adjuvant properties of bioactive keratin microparticles derived from porcupine (Hystrix indica) quills

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