Now That We’ve Found Love What Are We Gonna Do with It?

Hylton, Patrick; Miller, Hugh

doi:10.1177/0959354304043641

Cited by 3 publications

(1 citation statement)

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“…As McAdams (2001) notes, "It is painfully clear that life stories echo gender and class constructions in society and reflect, in one way or another, prevailing patterns of hegemony in the economic, political, and cultural contexts wherein human lives are situated" (p. 114). Hylton and Miller (2004) argue that "Black identity" can be understood as the articulation of successive dominant narratives or genres whereby the repertoire of available "texts" of identity is challenged, expanded, and reconfigured. The Fast Forward programme at the University of KwaZulu-Natal represents one form of practice engaging with these questions of identity, one way to challenge existing narratives and suggest alternative story-lines for young people.…”

Section: A Context Of Practicementioning

confidence: 99%

Narrative Possibilities

Bradbury

Miller

2010

Theory & Psychology

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The paper explores the ways in which narrative theories of identity may serve to interpret particular contextualized practices, working developmentally with South African youth. By locating narrative theories of identity in relation to two other theoretical frameworks, Vygotsky’s zone of proximal development and Ricoeur’s hermeneutics of textuality, we create a new theoretical approach for thinking about the possibilities and constraints for understanding sociohistorical questions of identity. As opposed to postmodern discursive deconstructions of the self or identity, we argue that the contextual imperatives of the developing world necessitate and demand the active interpretation and articulation of our-selves in stories and texts. It is suggested that this theoretical nexus offers a productive framework for practice.

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Section: A Context Of Practicementioning

confidence: 99%

Narrative Possibilities

Bradbury

Miller

2010

Theory & Psychology

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Counteraction and Transformation

Simon¹

2018

Supplementary Schools and Ethnic Minority Communities

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PREMONition: An algorithm for predicting the circadian clock-regulated molecular network

Bosman

Eelderink-Chen

Laing

et al. 2018

Preprint

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words)A transcriptional feedback loop is central to clock function in animals, plants and fungi. The clock genes involved in its regulation are specific to -and highly conserved within -the kingdoms of life. However, other shared clock mechanisms, such as phosphorylation, are mediated by proteins found broadly among living organisms, performing functions in many cellular sub-systems. Use of homology to directly infer involvement/association with the clock mechanism in new, developing model systems, is therefore of limited use. Here we describe the approach PREMONition, PREdicting Molecular Networks, that uses functional relationships to predict molecular circadian clock associations. PREMONition is based on the incorporation of proteins encoded by known clock genes (when available), rhythmically expressed clockcontrolled genes and non-rhythmically expressed but interacting genes into a cohesive network.After tuning PREMONition on the networks derived for human, fly and fungal circadian clocks, we deployed the approach to predict a molecular clock network for Saccharomyces cerevisiae, for which there are no readily-identifiable clock gene homologs. The predicted network was validated using gene expression data and a growth assay for sensitivity to light, a zeitgeber of circadian clocks of most organisms. PREMONition may be used to identify candidate clockregulated processes and thus candidate clock genes in other organisms.Keywords: circadian clock / interactome / S. cerevisiae / network / circadian rhythm the absence of identified clock genes. For instance, Neurospora crassa shows free-running rhythms and circadian entrainment without the clock gene frequency 3,4 and rhythms in the redox state of peroxiredoxin persist in many model genetic systems in the absence of transcription or of clock genes 5 . Paracrine signaling can sustain circadian rhythms in pacemaker (neuronal) tissue that lacks clock genes and displays no endogenous rhythm 6 . One interpretation of this is that feedback integral to circadian clocks spans multiple molecular 'levels', from transcription to metabolism. We conjecture that this multi-level response can be captured through functional relationships, referred to as functional interactions. We know of no models that explicitly attempt to integrate these different levels to more fully describe the mechanisms of the circadian clock. Here, we describe the method PREMONition, PREdicting MOlecular Networks, to construct multi-level (functional) molecular clock networks using publicly available datasets and bioinformatics tools. After tuning the method on clock genetic model systems, we deployed PREMONition to predict a molecular clock network in S. cerevisiae, an experimental system with a circadian phenotype that is not suited to genetic screens 7 . We validated the results of the yeast experiment in silico and in vivo. Methods like PREMONition, that span multiple levels in the cell, are essential to developing integrative models of complex biological processes. Results PREMONition applied to mod...

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Now That We’ve Found Love What Are We Gonna Do with It?

Cited by 3 publications

References 74 publications

Narrative Possibilities

Narrative Possibilities

Counteraction and Transformation

PREMONition: An algorithm for predicting the circadian clock-regulated molecular network

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