NOVELTY: a landmark study in phenotyping and endotyping chronic obstructive airway diseases in real clinical practice

Abstract

NOVELTY is a prospective real life observational study that investigates asthma, COPD and asthma/ COPD overlap over a period of years with the purpose to relate phenotype and endotype to clinical outcomes and disease trajectories https://bit.ly/3qERZRD

Development and validation of a predictive model combining patient-reported outcome measures, spirometry and exhaled nitric oxide fraction for asthma diagnosis

“…Given its high PPV, our model should now be tested in a primary care setting because it offers a simple and a quick way to make a first selection in patients with symptoms suggestive of asthma. Filling in a symptom questionnaire and performing a F ENO measurement followed by spirometry will take only 10 min, which is less time consuming than the classic reversibility test, which requires 15–20 min and was, otherwise, found to be insensitive in capturing excess airway variability in patients with preserved baseline airway calibre [ 9 , 11 ]. Furthermore, developing a digital health tool that integrates an algorithm based on our results might be a useful diagnostic/screening tool to disseminate in the primary care setting [ 34 , 35 ].…”

“…Although a common disease, the diagnosis of asthma may be all but trivial in clinical practice. In this respect, it is worth noting that in the recently published NOVELTY study only a minority of patients labelled as being asthmatic satisfied the bronchodilation criteria for asthma [ 10 , 11 ]. The reason is that lung function tests are often not performed and consequently diagnosis is reduced to the clinical history and signs at the physical examination [ 12 ].…”

“…There has been much emphasis on the utility of discovering and using biomarkers to help in the diagnosis [ 13 – 15 ]. In contrast, the respective value of symptoms as reported directly by patients has been somewhat neglected [ 5 , 11 ] and the recent ERS guidelines acknowledge the importance of new research focusing on detailed symptoms history [ 9 ]. Indeed, despite the increasing recognition of the need to include the patient's perspective in routine practice as captured by patient-reported outcome measures (PROMs) [ 16 , 17 ], few asthma studies have explored the contribution of patient-reported asthma symptoms in the diagnosis [ 18 , 19 ].…”