Novel zinc(II)phthalocyanines bearing azo-containing schiff base: Determination of pKa values, absorption, emission, enzyme inhibition and photochemical properties

Synthesis, Inhibitory Properties on the Metabolic Enzymes and Antioxidant Activity of a New Series Benzimidazole Derivatives

“…The DPPH radical scavenging activity of the synthesized compounds was measured using the method of Brand-Williams. 15,16,18,24,25 Briefly, 1200 microliter of 0.1 mM DPPH (2,2-diphenyl-1-picrylhydrazyl) solution in methanol was added to 300 µL of the synthesized compound solution in DMSO. After, in the dark for 50 min, decrease in absorbance at 517 nm was measured, using a UV-Visible spectrophotometer (1601UV-Shimadzu, Australia).…”

“…The production of ammonia was measured by indophenol method and used to determine the urease inhibitory activity. 20,21,25 The percentage remaining activity was calculated from the formula % Remaining Activity = [(ODtest)/(ODcontrol) x 100]. Thiourea (S1) and acetohydroxamic acid (S2) were used as standard urease inhibitors.…”

“…The inhibitory activity of each compound was determined using a slight modification of the reference methods. [24][25][26] A well known XO inhibitor (XOI), allopurinol (Sigma-Aldrich, St. Louis, USA), was used as a positive control for the inhibition test. Residual activities were calculated by comparing to control without inhibitor.…”

Synthesis, Characterization, and Investigation of Cholinesterase Inhibitory Properties of Novel Phthalocyanines

“…The many factors are thought to play a role in the formation of AD that includes oxidative stress, amyloid β deposits, neuronal cell destruction, τ‐protein aggregation, and low levels of acetylcholine (ACh) in the hippocampus and cortex areas . Cholinesterase enzymes [including acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE)] have crucial role on degradation of ACh, which is a neurotransmitter involved in memory and learning, and catalyze the hydrolysis of ACh into acetate and choline in cholinergic synapses . Thus, inhibition of the cholinesterase enzymes is important approach to regulate ACh level in patients.…”

The synthesis of axially disubstituted silicon phthalocyanines, their quaternized derivatives and first inhibitory effect on human cytosolic carbonic anhydrase isozymes hCA I and II

“…17,18 But, researches on biological study of SiPcs are quite limited in literature. [19][20][21][22][23][24][25] According to our knowledge, the carbonic anhydrase inhibitor properties of silicon phthalocyanines has not been reported in the literature. We report herein, the synthesis and characterization of the novel silicon(IV) phthalocyanine bearing [(2E)-3-[4-(dimethylamino)phenyl]-1-(4phenoxy)prop-2-en-1-one] group and its quaternized.…”