Novel water soluble Schiff base metal complexes: Synthesis, characterization, antimicrobial-, DNA cleavage, and anticancer activity

Shiju, C.; Dasan, Arish; Kumaresan, S.

doi:10.1016/j.molstruc.2020.128770

Cited by 40 publications

(22 citation statements)

References 49 publications

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“…Comparison of copper complexes with other metal complexes generally indicates that copper compounds are more effective antibacterial and/or antifungal agents [11,14,25,30,32,33,39,41,42,56]. This can be associated with such a distinctive feature of copper as its ability to redox transformations.…”

Section: Discussionmentioning

confidence: 99%

“…CF belongs to class II of the second-generation fluoroquino-lone-synthetic antibiotics that are active against both Gram-positive and Gram-negative bacteria. Copper complexes of the synthesized CF derivatives HL 39 -HL 44 showed sensitivity against S. aureus, E. coli, K. pneumonia, and ESBL positive K. pneumonia. The presence of copper(II) ions enhanced the antibacterial reactivity of the derivatives, illustrating the effect of the metal ion on the properties of the ligands.…”

Section: N-donor Ligandsmentioning

confidence: 98%

“…Water soluble transition metal (Cu(II), Co(II), Ni(II), and Zn(II)) complexes 34a-34d with N,N,Odonor ligand H 2 L 34 obtained from glycylglycine and 4nitrobenzaldehyde were synthesized [39]. Generally, it has been observed that metal chelates 34a-34d has more antimicrobial activity than the free ligand H 2 L 34 .…”

Section: N-donor Ligandsmentioning

confidence: 99%

“…The compound 38a almost inhibit the fungi about 73%. Сiprofloxacin (CF) derivatives HL 39 -HL 44 used for synthesis six copper complexes 39-44 general composition [Cu(L) 2 (H 2 O) x ]•yH 2 O [43]. CF belongs to class II of the second-generation fluoroquino-lone-synthetic antibiotics that are active against both Gram-positive and Gram-negative bacteria.…”

Section: N-donor Ligandsmentioning

confidence: 99%

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Recent Studies on the Antimicrobial Activity of Copper Complexes

Zalevskaya

Gur’eva

2021

Russ J Coord Chem

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The analysis of publications in 2020, devoted to the synthesis of copper(II) complexes and the study of their antimicrobial properties, indicates that this area of medicinal chemistry is promising. Organic compounds of various classes were studied as starting ligands. First of all, these are N-donor imines, amines, heterocyclic compounds, as well as N,O-donor ligands and sulfur-containing ligands. In most works, the fact of a higher biological activity of the metal complex in comparison with the corresponding ligand was established. Evaluating the influence of the nature of the metal on the antimicrobial activity of the metal complex, the authors most often come to the conclusion that it is copper(II) complexes that are the most effective inhibitors of the growth of pathogenic bacteria. The scale of the studies presented indicates a high interest in this group of metal complexes, and the results indicate good prospects for using copper complexes as antimicrobial drugs.

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Section: Discussionmentioning

confidence: 99%

Section: N-donor Ligandsmentioning

confidence: 98%

Section: N-donor Ligandsmentioning

confidence: 99%

Section: N-donor Ligandsmentioning

confidence: 99%

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Recent Studies on the Antimicrobial Activity of Copper Complexes

Zalevskaya

Gur’eva

2021

Russ J Coord Chem

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“…Complexes of transition metals either amplify the existing properties of ligand or introduced some new properties. The complexation of transition metals with the ligand is reported with biological activities such as, antitumor, antiinflammatory, anti-parasitic properties, as well as uses against other diseases [18][19] . The complexes of rare-earth ions have aroused much interest.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

IJPSR

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Hybrid molecules, furnished by combining coumarin and pyrazoles, have been synthesized in the present study. In addition, the binding ability of these coumarin-based molecules has been investigated for Nickel and less studied lanthanum. Lanthanum and nickel complexes with 4- 4b) were synthesized using lanthanum nitrate hexahydrate (La(NO 3 ).6H 2 O) and nickel dichloride hexahydrate (NiCl 2 .6H 2 O). The synthesized complexes 5a-d were isolated and characterized by IR, Mass, and 1 HNMR spectroscopy. The spectra of complexes 5a-d were interpreted on the basis of comparison with the spectrum of the free ligand. These complexes were screened for DNA photocleavage activity. Two complexes, 5a, and 5b, gave significantly good results found to degrade both forms of DNA (SC and NC). Our data give the reason to conclude that these compounds can act as lead compounds and should be submitted to further more detailed biological evaluation.

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Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

Abdel‐Rahman

Basha

Al–Farhan

et al. 2021

Applied Organom Chemis

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In this study, five novel complexes for Co(II), Ni(II), VO(II), Cr(III), and La(III) ions were synthesized from a tridentate NNO monobasic chelating Schiff base ligand, (Z)-2-((pyridin-2-ylimino)methyl)phenol (HL). Spectral and analytical tools were applied to elucidate the structural compositions of the new compounds. Then, geometry optimization was conducted for all the syntheses by the Gaussian 09 program via the density functional theory method to obtain optimal structures and the most essential parameters. Moreover, the biochemical behaviors of all the syntheses were explored based on the reactivity, which was tested against various cancer cell lines (HepG-2, MCF-7, and HCT-116). The complexes exhibited an interestingly antiproliferative potential against human cancer cell lines, and the cytotoxicities of the new complexes were arranged to follow the order: VOL > CrL > NiL > LaL > CoL > HL. The antioxidant behaviors of the complexes were studied using the DPPH assay, and VOL showed the maximum antioxidant activity, followed by LaL. The antibacterial activities of the HL ligand and its complexes were studied. Moreover, the binding nature of the complexes with calf thymus DNA (CT-DNA) was investigated based on the spectrophotometric absorption titration, viscosity, and gel electrophoresis methods. The binding ability of the complexes with CT-DNA was proposed to be just intercalation or replacement mode. The intrinsic binding constant K b was calculated and arranged based on the following order: VOL (5.2 Â 10 5 ) > CrL (3.6 Â 10 5 ) > NiL (3.3 Â 10 5 ) > LaL (3.0 Â 10 5 ) > CoL (1.12 Â 10 5 ) mol À1 dm À3 . Docking investigations were performed using the receptors of COVID-19's main protease viral protein (PDB ID: 6LU7) and Escherichia coli (gram [-ve] bacteria [PDB ID: 1fj4]).

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Novel water soluble Schiff base metal complexes: Synthesis, characterization, antimicrobial-, DNA cleavage, and anticancer activity

Cited by 40 publications

References 49 publications

Recent Studies on the Antimicrobial Activity of Copper Complexes

Recent Studies on the Antimicrobial Activity of Copper Complexes

Untitled

Synthesis, characterization, potential antimicrobial, antioxidant, anticancer, DNA binding, and molecular docking activities and DFT on novel Co(II), Ni(II), VO(II), Cr(III), and La(III) Schiff base complexes

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