Novel UV-transparent 2-component polyurethane resin for chip-on-board LED micro lenses

Bauer, J.; Gutke, Marko; Heinrich, F.; Edling, Matthias; Stoycheva, Vesela; Kaltenbach, Alexander; Burkhardt, Martin; Gruenefeld, Martin; Gamp, Matthias; Gerhard, Christoph; Steglich, Patrick; Steffen, Sebastian; Herzog, Michael; Dreyer, Christian; Schrader, Sigurd

doi:10.1364/ome.393844

Cited by 7 publications

(4 citation statements)

References 41 publications

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“…Generally, the pH of new formulations is maintained between 6 and 8 by using various buffer solutions in order to avoid altering the normal functioning of systems and tissues [54]. The narrow range of the refractivity index (1.59-1.61) for the three samples indicates their similarity; the literature is rather sparse in terms of values of the refractivity index for polymer drug carriers, but M. Iwazumi and A. Schneider reported a larger range (1.53-1.63) for PU coatings [55], while J. Bauer et al have reported higher values (1.55-1.75) for PU elastomer samples based on methylene-diphenyl diisocyanate and hexamethylene diisocyanate, respectively [56].…”

Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

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The delivery of nucleosides represents an interesting research trend in recent years due to their application in various viral infections. The main aims of this study were to develop and to characterize polyurethane particles that are intended to be used for the transport of nucleosides. Three samples have been prepared using aliphatic diisocyanates, a mixture of polyethylene glycol, polycaprolactone, and diols, respectively. The samples were characterized through refractivity measurements, drug loading efficacy, release and penetration rate investigations, FTIR and Raman spectroscopy, thermal analyses, Zetasizer, SEM, HDFa cells viability, and irritation tests on mice skin. The results indicate the obtaining of particles with sizes between 132 and 190 nm, positive Zeta potential values (28.3–31.5 mV), and a refractivity index around 1.60. A good thermal stability was found, and SEM images show a medium tendency to agglomerate. The samples’ color, pH, and electrical conductivity have changed only to a small extent over time, and the evaluations indicate an almost 70% encapsulation efficacy, a prolonged release, and that around 70% of particles have penetrated an artificial membrane in the first 24 h. The synthesized products should be tested in further clinical trials, and the current tests on cell cultures and mice skin revealed no side effects.

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Section: Discussionmentioning

confidence: 99%

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Borcan,

Vlase,

Vlase

et al. 2023

JFB

View full text Add to dashboard Cite

show abstract

“…Generally, the pH of new formulations is maintained between 6 and 8 by using various buffer solutions in order to avoid altering the normal functioning of systems and tissues [37]. The narrow range of refractivity index (1.59-1.61) for the three samples indicates their similarity; the literature is rather poor in values of the refractivity index for polymer drug carriers, but M. Iwazumi and A. Schneider reported a larger range (1.53-1.63) for PU coatings [38], while J. Bauer et al have reported higher values (1.55-1.75) for PU elastomer samples based on methylene-diphenyl diisocyanate and hexamethylene diisocyanate, respectively [39].…”

Section: Discussionmentioning

confidence: 98%

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

Borcan¹,

Vlase²,

Popescu³

et al. 2023

Preprint

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The drug delivery systems receive more and more attention for the control and treatment of many diseases due to their increased number in recent years. The main aims of this study were to develop and to characterize a polyurethane drug delivery system that it is intended to be used for the transmembrane transport of nucleosides. Three different samples have been synthesized based on aliphatic diisocyanates (hexamethylene diisocyanate, isophorone diisocyanate and lysine diisocyanate) as organic phase, respectively a mixture of polyethylene glycol, polycaprolactone diol and low molecular weight diols as aqueous phase. The samples were characterized by pH, refractivity index and solubility measurements, drug loading efficacy and release investigations, thermal behavior, Zetasizer, cells viability and irritation tests on mice skin. The results indicate the obtaining of different populations of neutral acido-basic particles with size between 132 and 190 nm; the Zeta potential values and SEM images show a medium tendency to form clusters, while UV-Vis evaluations indicate an almost 70% encapsulation efficacy, a prolonged release (45% of encapsulated substance is released in the first 5 days) and around 70% of particles have penetrated an artificial membrane in the first 24h. The synthesized products can be tested in further clinical trials, the currently tests on cells culture and mice skin revealing no side effects.

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“…4d. The contribution of BNNS in ameliorating the reflectance can be best understood from its higher refractive index (n BNNS ≈ 2.1) than both WPU (n WPU ≈ 1.4) and air (n air ≈ 1) 67,68 , which led to the multiscale mechanisms as discussed in the following. Macroscopically, the effective refractive index of solid pore walls was raised by adding BNNS, amplifying the difference in refractive index between solid and air so as to enhance the light scattering at their interfaces (Fig.…”

Section: Solar Reflectance Of Acamentioning

confidence: 99%

“…The thickness of all models was fixed at 110 µm. The effective refractive index and extinction coefficient of the pore walls consisting of WPU and BNNS 67,68 were calculated based on the volume fraction of BNNS in the WPU aerogels, assuming perfect alignments and even distribution of BNNS in the pore alignment direction.…”

Section: Numerical Simulationsmentioning

confidence: 99%

Scalable anisotropic cooling aerogels by additive freeze-casting

et al. 2022

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Cooling in buildings is vital to human well-being but inevitability consumes significant energy, adding pressure on achieving carbon neutrality. Thermally superinsulating aerogels are promising to isolate the heat for more energy-efficient cooling. However, most aerogels tend to absorb the sunlight for unwanted solar heat gain, and it is challenging to scale up the aerogel fabrication while maintaining consistent properties. Herein, we develop a thermally insulating, solar-reflective anisotropic cooling aerogel panel containing in-plane aligned pores with engineered pore walls using boron nitride nanosheets by an additive freeze-casting technique. The additive freeze-casting offers highly controllable and cumulative freezing dynamics for fabricating decimeter-scale aerogel panels with consistent in-plane pore alignments. The unique anisotropic thermo-optical properties of the nanosheets combined with in-plane pore channels enable the anisotropic cooling aerogel to deliver an ultralow out-of-plane thermal conductivity of 16.9 mW m−1 K−1 and a high solar reflectance of 97%. The excellent dual functionalities allow the anisotropic cooling aerogel to minimize both parasitic and solar heat gains when used as cooling panels under direct sunlight, achieving an up to 7 °C lower interior temperature than commercial silica aerogels. This work offers a new paradigm for the bottom-up fabrication of scalable anisotropic aerogels towards practical energy-efficient cooling applications.

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Novel UV-transparent 2-component polyurethane resin for chip-on-board LED micro lenses

Cited by 7 publications

References 41 publications

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

The Influence of an Isocyanate Structure on a Polyurethane Delivery System for 2′-Deoxycytidine-5′-monophosphate

Synthesis and Assessment of a Polyurethane Carrier Used for the Transmembrane Transfer of 2'-Deoxycytidine-5'-monophosphate sodium salt

Scalable anisotropic cooling aerogels by additive freeze-casting

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