Novel Use of Platelet Rich Fibrin Membrane in Transcanal Myringoplasty: A Prospective Study

Shukla, Anirudh; Kaurav, Yogesh Singh; Vatsyayan, Richa

doi:10.1007/s12070-020-01851-8

Cited by 11 publications

(3 citation statements)

References 21 publications

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“…In prospective research comprising 41 patients, Shukla et al [13] evaluated the utilization of platelet-rich fibrin membrane in transcanal myringoplasty. Tympanic membrane perforations were repaired using PRF membrane, and 85.4% of the patients in this study experienced a good outcome.…”

Section: Abgmentioning

confidence: 99%

Evaluation of the use of autologous platelet-rich fibrin in myringoplasty operation

Naga

Elsharnouby

Ali

et al. 2022

Egypt J Otolaryngol

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Background Platelet-rich fibrin (PRF) which is considered a second-generation platelet-rich plasma having a high content of growth factors could be implied as a sealant and adjuvant to grafting materials during tympanoplasty operation. This work aimed to evaluate the role of autologous platelet-rich fibrin as an adjuvant in type 1 tympanoplasty (myringoplasty) for the closure of central tympanic membrane perforations. A prospective comparative study was conducted including one-hundred patients with chronic suppurative otitis media with dry central TM perforations. The patients were classified into two equal groups: group A (case group) was subjected to myringoplasty operation with the use of autologous PRF added to the temporalis fascia graft, and group B (control group) was subjected to myringoplasty operation using graft only without PRF. Both groups were assessed for successful closure of perforation defined as an intact eardrum, success in terms of hearing defined as closure of air-bone gap down to 10 dB or lesser, and hearing gain at 6 months postoperatively. Results At 6 months postoperatively, the success rate (graft taking) in group A (90%) was significantly higher than in group B (70%). Success in terms of air-bone gap closure (< 10 dB) revealed that in group A, success was achieved in 39 patients (78%), which was significantly higher than in group B 27 patients (54 %). Air-bone gap at 6 months postoperatively was more in the graft taken cases in the case group than in the control group with a significant difference. There was a nonsignificant correlation between graft uptake and either hemoglobin or platelet concentrations in both groups. In addition, there was a nonsignificant correlation between graft uptake and the size of the perforation in both groups. Conclusion Platelet-rich fibrin is a cheap, cost-effective, and completely autologous platelet concentrate with enriched growth factors. It improves the overall success rate of myringoplasty with no noticeable side effects.

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Section: Abgmentioning

confidence: 99%

Evaluation of the use of autologous platelet-rich fibrin in myringoplasty operation

Naga

Elsharnouby

Ali

et al. 2022

Egypt J Otolaryngol

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“…Hearing loss and perforation dimensions have a strong quantitative relationship. The myringoplasty treatment helps the patient hear better [7][8] . In my studies, I have demonstrated that big tympanic membrane perforations following successful myringoplasty lead to greater improvements in hearing [9][10] .…”

Section: Introductionmentioning

confidence: 99%

Hearing Improvement after Myringoplasty in Association with the Tympanic Membrane Perforation Size

Khan¹,

Khan²,

Rasheed³

et al. 2023

PJMHS

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Objectives: To evaluate hearing improvement following successful myringoplasty based on the degree of tympanic membrane perforation. Methods: This cross-sectional study was held in the department of ENT of Aziz Bhatti Shaheed Teaching Hospital and ENT, Head and Neck Surgery department, Pak International Medical College and Peshawar Institute of Medical Sciences (PIMS), Hayatabad Peshawar for the duration from December 2021 to November 2022. Myringoplasty procedures were performed on 80 individuals in total following thorough history-taking, clinical testing, and research. Hearing was tested both before and after the operation. A variety of tables, charts, and drawings are used to present the analysed data. Results: For minor perforations, 27.81 dB was the mean air-bone gap, 7.21 dB was the mean bone conduction threshold, and 33.40 dB was the mean air conduction threshold prior to surgery. In medium-sized perforations, 32.78 dB was the mean air-bone gap, 10.10 dB was the mean bone conduction threshold and 46.21 dB was the mean air conduction threshold prior to surgery. In the instance of a large perforation, 48.86 dB was the mean air-bone gap, 62.01 dB was the mean air conduction threshold, and 15.20 dB was the mean bone conduction threshold prior to surgery. After myringoplasty, the mean postoperative air-bone gap for medium, large and small perforations was 14.22 dB, 22.62 dB and 6.24 dB, correspondingly. Using the unpaired test, it was determined that the difference in airbone gap between minor and medium sized perforations closure was statistically significant. Conclusions: After myringoplasty of large size perforations, hearing gain is improved significantly. Myringoplasty and hearing enhancement are key words. Keywords: Myringoplasty, Hearing Improvement, Tympanic membrane perforations

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“…Cholesteatoma, persistent otorrhea, and eventual hearing loss can develop if surgical treatment is delayed or avoided. To wit: (Shukla A et al,2020) Myringoplasty is the recommended surgical procedure for repairing a ruptured tympanic membrane. Several different grafting materials and myringoplasty procedures have been tried to heal the perforated tympanic membrane.…”

Section: Introductionmentioning

confidence: 99%

Endoscopic closure of tympanic membrane perforations by platelet-richplasma laden cartilage with perichondrium

Youssef

Alboghdady

Salah

et al. 2022

ijhs

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Background: Myringoplasty surgery, also known as tympanic membrane repair, is performed to correct hearing loss brought on by TM perforation and to eliminate recurrent ear discharge. Platelets are the primary players in the process of tissue healing. They provide essential growth factors that stimulate fibroblasts to produce new blood vessels and lay down extracellular matrix. The study aim: Is to assess the efficacy of incorporating plateletrichplasma into tragal cartilage grafts with its perichondrium in order to speed healing and enhance the results of endoscopic transcanalmyringoplasty. Patients, and methods: Fifty people suffer from dry central TM perforation participated in this prospective case-control study. Under local anaesthesia, each of them had endoscopic transcanal myringoplasty by using tragal perichondrium grafts. 25 patients underwent myringoplasty surgery and also received platelet-richplasma (PRP) from the same patient in group A, compared to 25 patients in group B who underwent myringoplasty surgery but did not get PRP. Results: There were 25 patients in each group, and no statistically significant demographic differences existed between the two groups. A p-value of (0.01) indicates that there was a significant difference between the plattelet-rich plasma group's (100%) and the non-plattelet-rich plasma group's (72%) graft absorption success rates.

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Novel Use of Platelet Rich Fibrin Membrane in Transcanal Myringoplasty: A Prospective Study

Cited by 11 publications

References 21 publications

Evaluation of the use of autologous platelet-rich fibrin in myringoplasty operation

Evaluation of the use of autologous platelet-rich fibrin in myringoplasty operation

Hearing Improvement after Myringoplasty in Association with the Tympanic Membrane Perforation Size

Endoscopic closure of tympanic membrane perforations by platelet-richplasma laden cartilage with perichondrium

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