Novel use of 3T MRI in assessment of optic nerve volume in glaucoma

Ramli, Norlina; Sidek, Sabrilhakim; Rahman, Fazliny Abd; Peyman, Mohammadreza; Zahari, Mimiwati; Rahmat, Kartini; Ramli, Norlisah

doi:10.1007/s00417-014-2622-6

Cited by 23 publications

(14 citation statements)

References 26 publications

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“…[ 44 ] Using a different MRI protocol, Ramli et al observed a significantly lower ION volume in advanced glaucoma compared to mild glaucoma or control groups, but no difference was found between mild glaucoma and control groups. [ 21 ] Our results are, at least in part, consistent with those studies, since the advanced glaucoma group had smaller ION diameter and cross-sectional area than the control group in all studied distances from the eye. This difference was also observed when the advanced glaucoma group was compared with the mild glaucoma group, except for the ION cross-sectional area at 5 mm from the eye.…”

Section: Discussionsupporting

confidence: 92%

“…[ 14 , 43 ] Using this method, we found smaller ION dimensions at different distances from the eye in glaucomatous relative to normal ones, which is consistent with previous MRI studies. [ 15 , 21 , 44 ] In one such MRI study, Chen et al described a smaller cross-sectional area of the ION in patients with advanced glaucoma compared to an age- and sex-matched control group. [ 44 ] Using a different MRI protocol, Ramli et al observed a significantly lower ION volume in advanced glaucoma compared to mild glaucoma or control groups, but no difference was found between mild glaucoma and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…[ 18 ] In a 3T MRI study, Lagrèze et al found a positive correlation between the ION mean diameter at 15 mm behind the globe and RNFLT measured with scanning laser polarimetry. [ 15 ] Ramli et al reported a moderate correlation between OCT-derived RNFLT and the ION volume,[ 21 ] the estimation of which was also influenced by the location where the ION volume was measured. The histological arrangement of the ION may help explain the stronger structural associations found in the most distal segments.…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 , 20 ] Nevertheless, only few studies investigated the correlation between outcomes from ocular tests and 3T MRI structural findings of the anterior visual pathway in human glaucoma. [ 15 , 16 , 21 , 22 ] Although some significant associations were reported, such correlation analyses involving the ION and/or the LGN remain unclear and need further clarification, given the differences among those studies regarding sample characteristics (including age of participants and stages of glaucomatous damage), MRI data acquisition protocols and statistical models applied. In addition, none of those studies considered the subtypes of visual pathway in their structure-function correlation analyses.…”

Section: Introductionmentioning

confidence: 99%

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Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma

et al. 2018

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PurposeTo analyze the correlation between structural characteristics of intraorbital optic nerve (ION) and lateral geniculate nucleus (LGN) measured by 3-Tesla magnetic resonance imaging (3T MRI), and the severity of glaucomatous damage.MethodsIn this cross-sectional study, 41 glaucoma patients and 12 age- and sex-matched controls underwent standard automated perimetry (SAP) and frequency doubling technology (FDT) as functional evaluation; optic disc stereophotograph, spectral-domain optical coherence tomography (OCT) and confocal scanning laser tomography as ocular structural evaluation; and 3T MRI. Structure-structure and structure-function correlation were performed using bootstrap resampling method for clustered data.ResultsThe ION mean diameter and cross-sectional area were different between glaucoma and control groups at 5mm and 10mm (all, p≤0.011) from the globe, but not at 15mm (both, p≥0.067). LGN height was significantly lower in glaucoma group (p = 0.005). OCT rim area and functional parameters (SAP and FDT) correlated significantly with all ION segments, showing stronger correlations at 10 and 15 mm. ION parameters at 10 and 15 mm presented mild-to-moderate correlation with OCT peripapillary nerve fiber layer thickness, and ION at 15mm had mild association with the neuroretinal rim area on stereophotographs. Although LGN height was significantly smaller in glaucoma group (p = 0.005), LGN parameters were not associated with any ocular structural or functional parameter.ConclusionAssessment of central and peripheral nervous systems using 3T MRI confirmed that glaucoma patients had smaller ION dimensions and LGN height compared to the control group. In general, ION dimensions presented mild to moderate correlations with functional and ocular structural parameters. Although ION had significant correlations at any distance from the eye, the ION distal locations correlated better with OCT results and functional parameters. However, LGN parameters were not associated with functional or ocular structural parameters.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma

et al. 2018

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“…Ramli and collegues 17 used 3 Tesla magnetic resonance imaging (MRI) to evaluate optic nerve head volume and found significantly lower nerve volume in both eyes of patients with severe and mild glaucoma groups compared to controls. Optic nerve volume less than 236 mm(3) was 96 % sensitive and 80% specific for severe glaucoma by visual field criteria.…”

Section: Introductionmentioning

confidence: 99%

One Year of Glaucoma Research in Review—2013 to 2014

Tassel

Radcliffe

Demetriades³

2015

Asia-Pacific Journal of Ophthalmology

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Purpose The purpose of this study was to provide the practicing clinical ophthalmologist with an update of relevant glaucoma literature published from 2013 to 2014. Design Literature review. Methods The authors conducted a 1-year (October 1, 2013, to September 30, 2014) English-language glaucoma literature search on PubMed of articles containing “glaucoma” or “glaucomatous” with title/abstract as a filter. Medical Subject Headings (MeSH) filtered searching was not performed because of the newness of the reviewed material. Results Literature review yielded 2,314 articles, after which we excluded reviews and letters to the editor. We highlighted articles featuring new or updated approaches to the pathophysiology, diagnosis, or treatment of glaucoma and gave preference to human research. Conclusions This review features literature that is of interest to ophthalmologists in practice and also highlights studies that may provide insight to future developments applicable to clinical ophthalmology.

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Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

Zhang

Xie

et al. 2021

Human Brain Mapping

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The retinogeniculate visual pathway (RGVP) conveys visual information from the retina to the lateral geniculate nucleus. The RGVP has four subdivisions, including two decussating and two nondecussating pathways that cannot be identified on conventional structural magnetic resonance imaging (MRI). Diffusion MRI tractography has the potential to trace these subdivisions and is increasingly used to study the RGVP. However, it is not yet known which fiber tracking strategy is most suitable for RGVP reconstruction. In this study, four tractography methods are compared, including constrained spherical deconvolution (CSD) based probabilistic (iFOD1) and deterministic (SD-Stream) methods, and multi-fiber (UKF-2T) and single-fiber (UKF-1T) unscented Kalman filter (UKF) methods. Experiments use diffusion MRI data from 57 subjects in the Human Connectome Project. The RGVP is identified using regions of interest created by two clinical experts. Quantitative anatomical measurements and expert anatomical judgment are used to assess the advantages and limitations of the four tractography methods. Overall, we conclude that UKF-2T and iFOD1 produce the best RGVP reconstruction results. The iFOD1 method can better quantitatively estimate the percentage of decussating fibers, while the UKF-2T method produces reconstructed RGVPs that are judged to better correspond to the known anatomy and have the highest spatial overlap across subjects.Overall, we find that it is challenging for current tractography methods to both accurately Jianzhong He and Fan Zhang are co-first-authors.

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Novel use of 3T MRI in assessment of optic nerve volume in glaucoma

Abstract: MRI measured optic nerve volume is a reliable method of assessing glaucomatous damage beyond the optic nerve head. A value of 236 mm(3) and below can be used to define severe glaucoma.

Cited by 23 publications

References 26 publications

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma

Structural and functional analyses of the optic nerve and lateral geniculate nucleus in glaucoma

One Year of Glaucoma Research in Review—2013 to 2014

Comparison of multiple tractography methods for reconstruction of the retinogeniculate visual pathway using diffusion MRI

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