Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: Curcumin

Baghbani, Fatemeh; Chegeni, Mahdieh; Moztarzadeh, Fathollah; Hadian-Ghazvini, Samaneh; Raz, Majid

doi:10.1016/j.msec.2016.11.107

Cited by 69 publications

(51 citation statements)

References 48 publications

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“…As an example, perfluorohexane nanodroplets with the shell of chitosan were synthesized through emulsion chemistry, and were subsequently loaded with curcumin [101]. The loaded nanodroplets were successfully able to have on-demand release the drug in response to external ultrasound stimuli.…”

Section: Ultrasound-responsive Drug Releasementioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

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Currently, surgical operations, followed by systemic drug delivery, are the prevailing treatment modality for most diseases, including cancers and trauma-based injuries. Although effective to some extent, the side effects of surgery include inflammation, pain, a lower rate of tissue regeneration, disease recurrence, and the non-specific toxicity of chemotherapies, which remain significant clinical challenges. The localized delivery of therapeutics has recently emerged as an alternative to systemic therapy, which not only allows the delivery of higher doses of therapeutic agents to the surgical site, but also enables overcoming post-surgical complications, such as infections, inflammations, and pain. Due to the limitations of the current drug delivery systems, and an increasing clinical need for disease-specific drug release systems, hydrogels have attracted considerable interest, due to their unique properties, including a high capacity for drug loading, as well as a sustained release profile. Hydrogels can be used as local drug performance carriers as a means for diminishing the side effects of current systemic drug delivery methods and are suitable for the majority of surgery-based injuries. This work summarizes recent advances in hydrogel-based drug delivery systems (DDSs), including formulations such as implantable, injectable, and sprayable hydrogels, with a particular emphasis on stimuli-responsive materials. Moreover, clinical applications and future opportunities for this type of post-surgery treatment are also highlighted.

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Section: Ultrasound-responsive Drug Releasementioning

confidence: 99%

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Askari

Seyfoori

Amereh

et al. 2020

Gels

View full text Add to dashboard Cite

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“…The in vitro release studies showed that 63.5% of the incorporated curcumin was released over 4 min by sonication at a frequency of 1 MHz. Cytotoxicity studies showed that Cur/chitosan/PFH nanodroplets in the presence of ultrasound induce toxic effects in 4T1 cancer cells (Baghbani et al, 2017). which is beneficial for biomedical applications.…”

Section: Chitosan-based Stimuli-sensitive Formulationsmentioning

confidence: 99%

Chitosan‐based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects

Saheb

Fereydouni

Nemati

et al. 2019

Journal Cellular Physiology

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Effective drug delivery is one of the most important issues associated with the administration of therapeutic agents that have low oral bioavailability. Curcumin is an active ingredient in the turmeric plant, which has low oral bioavailability due to its poor aqueous solubility. One strategy that has been considered for enhancing the aqueous solubility, and, thus, its oral bioavailability, is the use of chitosan as a carrier for curcumin. Chitosan is a biodegradable and biocompatible polymer that is relatively water‐soluble. Therefore, various studies have sought to improve the aqueous solubility of chitosan. The use of different pharmaceutical excipients and formulation strategies has the potential to improve aqueous solubility, formulation processing, and the overall delivery of hydrophobic drugs. This review focuses on various methods utilized for chitosan‐based delivery of curcumin.

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“…Baghbani et al [ 93 ] developed smart curcumin-loaded chitosan/perfluorohexane nanodroplets capable of several functions. These nanodroplets were developed for contrast-ultrasound imaging and evaluated its cytotoxicity in vitro on 4T1 human breast cancer cells.…”

Section: Ultrasonography Imagingmentioning

confidence: 99%

Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes

Ma¹,

Jin

Wang³

et al. 2017

Contrast Media & Molecular Imaging

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Although advancements in medical technology supporting cancer diagnosis and treatment have improved survival, these technologies still have limitations. Recently, the application of noninvasive imaging for cancer diagnosis and therapy has become an indispensable component in clinical practice. However, current imaging contrasts and tracers, which are in widespread clinical use, have their intrinsic limitations and disadvantages. Nanotechnologies, which have improved in vivo detection and enhanced targeting efficiency for cancer, may overcome some of the limitations of cancer diagnosis and therapy. Theranostic nanoparticles have great potential as a therapeutic model, which possesses the ability of their nanoplatforms to load targeted molecule for both imaging and therapeutic functions. The resulting nanosystem will likely be critical with the growth of personalized medicine because of their diagnostic potential, effectiveness as a drug delivery vehicle, and ability to oversee patient response to therapy. In this review, we discuss the achievements of modern nanoparticles with the goal of accurate tumor imaging and effective treatment and discuss the future prospects.

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Novel ultrasound-responsive chitosan/perfluorohexane nanodroplets for image-guided smart delivery of an anticancer agent: Curcumin

Cited by 69 publications

References 48 publications

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Stimuli-Responsive Hydrogels for Local Post-Surgical Drug Delivery

Chitosan‐based delivery systems for curcumin: A review of pharmacodynamic and pharmacokinetic aspects

Molecular Imaging of Cancer with Nanoparticle-Based Theranostic Probes

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