Novel ultrasensitive immunoassay for the selective quantification of tau oligomers and related soluble aggregates
Tohidul Islam,
Hlin Kvartsberg,
Anuradha Sehrawat
et al.
Abstract:INTRODUCTIONTau aggregation into paired helical filaments and neurofibrillary tangles is characteristic of Alzheimer's disease (AD) and related disorders. However, biochemical assays for the quantification of soluble, earlier‐stage tau aggregates are lacking. We describe an immunoassay that is selective for tau oligomers and related soluble aggregates over monomers.METHODSA homogeneous (single‐antibody) immunoassay was developed using a novel anti‐tau monoclonal antibody and validated with recombinant and brai… Show more
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