Novel ultrafiltration membranes with adjustable charge density based on sulfonated poly(arylene ether sulfone) block copolymers and their tunable protein separation performance

Kumar, Mahendra; Ulbricht, Mathias

doi:10.1016/j.polymer.2013.09.003

Cited by 59 publications

(36 citation statements)

References 57 publications

(127 reference statements)

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“…5 The transport of proteins across the charged UF membranes is also dependent on the type and strength of electrostatic interactions between the membrane and the protein at a specific solution pH. 3,9,10,32,33 Thus, the selective separation of proteins using charged hybrid UF membranes is, in principle, possible at a controlled pH and applied transmembrane pressure. To the best of our knowledge, the fabrication of positively charged hybrid UF membranes with improved permeability and antifouling ability based on quaternized polysulfone and GO nanosheets has not been reported previously.…”

Section: Introductionmentioning

confidence: 99%

Quaternized polysulfone and graphene oxide nanosheet derived low fouling novel positively charged hybrid ultrafiltration membranes for protein separation

et al. 2015

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Low fouling novel positively charged hybrid ultrafiltration membranes with adjustable charge density were fabricated from blends of polysulfone (PSf) and quaternized polysulfone (QPSf) in combination with varied fractions of graphene oxide (GO) nanosheets by a non-solvent induced phase separation method. Fourier transform infrared spectroscopy in the attenuated total reflection mode, scanning electron microscopy, outer surface zeta potential and contact angle studies were conducted to characterize the morphologies of hybrid membranes, structures, charge and surface properties. Results confirmed the fabrication of porous, hydrophilic and positively charged membranes. The water permeabilities (flux) andantifouling ability of membranes with protein solution were dependent on the fraction of quaternary ammonium groups and GO nanosheets in the membranes matrix. Antifouling ability of membranes was improved after the incorporation of GO nanosheets. In addition, 2 irreversible protein fouling of membranes was substantially decreased with increasing fraction of GO nanosheets (%). The transmission of protein as a function of solution pH and the fraction of GO nanosheets (%) in the membranes was studied for two model proteins (bovine serum albumin; BSA or lysozyme; LYZ). The transmission of BSA or LYZ was controlled by size exclusion and the fraction of GO nanosheets in the membranes matrix. The highest transmission of proteins at their isoelectric points was obtained for membrane containing 2 wt% of GO nanosheets to total weight of polymers.

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Section: Introductionmentioning

confidence: 99%

Quaternized polysulfone and graphene oxide nanosheet derived low fouling novel positively charged hybrid ultrafiltration membranes for protein separation

et al. 2015

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“…Absorption peaks observed in 3000-3700 cm −1 for Piranha treated PP membrane ( Fig. 7(b)) are corresponded to the stretching vibration of O H (Pavia et al, 2008;Kumar and Ulbricht, 2014) confirm that OH functional group have been successfully generated on the surface of the Piranha treated PP membrane. Moreover, comparing results of Fig.…”

Section: Atr-ftirmentioning

confidence: 81%

Study on the fouling behavior of silica nanocomposite modified polypropylene membrane in purification of collagen protein

Ahsani

Yegani

2015

Chemical Engineering Research and Design

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“…Other membranes frequently used are depth filters or high performance tangential flow membranes which can be neutral or charged [16,111]. Kumar et al (2013) separated biomolecules based on their charge by charged ultrafiltration membranes [113,114].…”

Section: Non-chromatographic Separationsmentioning

confidence: 99%

Trends in Upstream and Downstream Process Development for Antibody Manufacturing

2014

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A steady increase of product titers and the corresponding change in impurity composition represent a challenge for development and optimization of antibody production processes. Additionally, increasing demands on product quality result in higher complexity of processes and analytics, thereby increasing the costs for product work-up. Concentration and composition of impurities are critical for efficient process development. These impurities can show significant variations, which primarily depend on culture conditions. They have a major impact on the work-up strategy and costs. The resulting "bottleneck" in downstream processing requires new optimization, technology and development approaches. These include the optimization and adaptation of existing unit operations respective to the new separation task, the assessment of alternative separation technologies and the search for new methods in process development. This review presents an overview of existing methods for process optimization and integration and indicates new approaches for future developments.

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Novel ultrafiltration membranes with adjustable charge density based on sulfonated poly(arylene ether sulfone) block copolymers and their tunable protein separation performance

Cited by 59 publications

References 57 publications

Quaternized polysulfone and graphene oxide nanosheet derived low fouling novel positively charged hybrid ultrafiltration membranes for protein separation

Quaternized polysulfone and graphene oxide nanosheet derived low fouling novel positively charged hybrid ultrafiltration membranes for protein separation

Study on the fouling behavior of silica nanocomposite modified polypropylene membrane in purification of collagen protein

Trends in Upstream and Downstream Process Development for Antibody Manufacturing

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