Novel Type of Chronic Wasting Disease Detected in Moose (<i>Alces alces</i>), Norway

Pirisinu, Laura; Tran, Linh; Chiappini, Barbara; Vanni, Ilaria; Bari, Michele Angelo Di; Vaccari, Gabriele; Vikøren, Turid; Madslien, Knut; Våge, Jørn; Spraker, Terry R.; Mitchell, Gordon; Balachandran, Aru; Baron, Thierry; Casalone, Cristina; Rolandsen, Christer Moe; Røed, Knut; Agrimi, Umberto; Nonno, Romolo; Benestad, Sylvie L.

doi:10.3201/eid2412.180702

Cited by 109 publications

(174 citation statements)

References 34 publications

Supporting

Mentioning

160

Contrasting

Order By: Relevance

“…Therefore, lymphoid tissues are very useful for diagnostic purposes and surveillance. Nevertheless, in the referred atypical CWD, no PrP sc was detected in lymphoid tissue [31], similar to that described in heterozygote ARR sheep affected with classical scrapie as well as atypical scrapie. In those cases, lymphoid tissues infectivity should be further studied like it was in atypical scrapie, demonstrating that infectivity can accumulate in lymphoid tissues even with no detectable PrP sc [245].…”

Section: Confirmatory Testingsupporting

confidence: 82%

“…The biochemical analysis and immunohistochemistry (IHC) distribution of PrP sc from Norway reindeer revealed a pattern indistinguishable from North America isolates [30]. Remarkably, in CWD-affected moose in Norway, a different phenotype was observed in both PrP sc distribution and biochemical features, suggesting a presence of a different type of CWD prion strain in moose from this country (designated Nor-16CWD) [31] (Figure 1).…”

Section: Molecular Basis Of Transmissible Spongiform Encephalopathiesmentioning

confidence: 92%

“…Recently, a different neuropathologic phenotype, characterized mainly by intraneuronal deposition of PrP sc and few immunostaining at the dorsal motor of the vagus nerve, was observed in the putative atypical CWD detected in Norwegian moose [31].…”

Section: Confirmatory Testingmentioning

confidence: 99%

See 2 more Smart Citations

TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control

Machado¹,

Orge²,

Pires³

et al. 2019

Wildlife Population Monitoring

View full text Add to dashboard Cite

Among the transmissible spongiform encephalopathies (TSEs), chronic wasting disease (CWD) in cervids is now the rising concern within Europe. CWD will be outlined in this chapter gathering its epidemiology, transmission, diagnosis, genetics, and control. Prion diseases are fatal neurodegenerative diseases characterized by the accumulation of an abnormal isoform of the prion protein (PrP c), usually designated by PrP sc or prion. CWD is a prion disease of natural transmission affecting cervids detected mainly in North America. The first European case was detected in Norway, in 2016, in a wild reindeer; until April 2018, a total of 23 cases were described. The definite diagnosis is postmortem, performed in target areas of the brain and lymph nodes. Samples are first screened using a rapid test and, if positive, confirmed by immunohistochemistry and Western immunoblotting. It is not possible to establish a culling plan based on the genotype, once affected animals appear with all genotypes. However, some polymorphisms seem to result in longer incubation periods or confer a reduced risk. The control is not easy in captive cervids and even more in the wildlife; some recommendations have been proposed in order to understand the danger and impact of CWD on animal and public health.

show abstract

Section: Confirmatory Testingsupporting

confidence: 82%

Section: Molecular Basis Of Transmissible Spongiform Encephalopathiesmentioning

confidence: 92%

See 1 more Smart Citation

TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control

Machado¹,

Orge²,

Pires³

et al. 2019

Wildlife Population Monitoring

View full text Add to dashboard Cite

show abstract

“…Animal prion diseases continue to emerge, recently with variants of scrapie and BSE, a camel prion disease in Algeria and chronic wasting disease in Scandinavian wild reindeer and moose . What are the risks for animal prions infecting humans?…”

Section: Similarities and Differences Between Bona Fide Prion Diseasementioning

confidence: 99%

Recent advances on the molecular pathogenesis of prion diseases

Glatzel

Sigurdson

2019

Brain Pathology

View full text Add to dashboard Cite

“…Chronic wasting disease (CWD) is a transmissible spongiform encephalopathy (TSE) affecting ruminants of the Cervidae family [1], like Creutzfeldt-Jakob disease (CJD) in humans, bovine spongiform encephalopathy (BSE) in cattle, and scrapie in small ruminants. CWD expanded its geographic distribution and possibly its prion strain diversity with the emergence in Eurasian reindeer (Rangifer tarandus) [2] and moose [3] in Norway in 2016. Previously, this disease had been confined to North America and the Republic of Korea, reported for the first time in Colorado, USA in 1967.…”

Section: Introductionmentioning

confidence: 99%

Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus)

Güere

Våge

Tharaldsen

et al. 2019

Prion

Self Cite

View full text Add to dashboard Cite

The emergence of CWD in Europe in 2016 and the first natural infection in wild reindeer warranted disease management. This led to the testing of 2424 hunted or culled reindeer during 2016-2018, from the infected subpopulation in the Nordfjella mountain range in Southern Norway. To identify any association between PRNP variation and CWD susceptibility, we characterized the open reading frame of the PRNP gene in 19 CWD positive reindeer and in 101 age category-and sex-matched CWD negative controls. Seven variant positions were identified: 6 single nucleotide variants (SNVs) and a 24 base pair (bp) deletion located between nucleotide position 238 and 272, encoding four instead of five octapeptide repeats. With a single exception, all variant positions but one were predicted to be nonsynonymous. The synonymous SNV and the deletion are novel in reindeer. Various combinations of the non-synonymous variant positions resulted in the identification of five PRNP alleles (A-E) that structured into 14 genotypes. We identified an increased CWD risk in reindeer carrying two copies of the most common allele, A, coding for serine in position 225 (Ser225) and in those carrying allele A together with the 24 bp deletion. ARTICLE HISTORY

show abstract

Novel Type of Chronic Wasting Disease Detected in Moose (Alces alces), Norway

Cited by 109 publications

References 34 publications

TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control

TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control

Recent advances on the molecular pathogenesis of prion diseases

Chronic wasting disease associated with prion protein gene (PRNP) variation in Norwegian wild reindeer (Rangifer tarandus)

Contact Info

Product

Resources

About