Novel two wavelength spectrophotometric methods for simultaneous determination of binary mixtures with severely overlapping spectra

Lotfy, Hayam M.; Saleh, Sarah S.; Hassan, Nagiba Y.; Salem, Hesham

doi:10.1016/j.saa.2014.10.084

Cited by 37 publications

(17 citation statements)

References 35 publications

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“…This method [37] is an extension for amplitude modulation method (AM) and advanced amplitude modulation (AMM) [37].…”

Section: Theoretical Background Induced Amplitude Modulation Methods (mentioning

confidence: 99%

“…Induced dual-wavelength method for PSE (IDW) The principle here is abolishing the interfering element's absorbance between two certain wavelengths. On the contrary of the ordinary dual wavelength method (DW), this method is used when the difference in absorbance (ΔA) of interfering element is not equal zero [37].…”

Section: For Determination Of Psementioning

confidence: 99%

“…The recently developed (IAM) method [37] was introduced for the severely overlapped spectra. In this work, the newly developed approach was applied concerned with the partially overlapped spectra where one of the spectra was extended than the other one.…”

Section: Manipulation Of the Ratio Spectra Of The Mixtures Using Normmentioning

confidence: 99%

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Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

et al. 2019

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Background: Simple, specific, accurate, and precise spectrophotometric methods are progressed and validated for concurrent analysis of pseudoephedrine sulphate (PSE) and loratadine (LOR) in their combined dosage form depending on spectral analysis procedures. In this binary mixture, pseudoephedrine (PSE) could be determined by using its resolved spectrum of zero-order absorption at 256.8 nm after subtraction of the spectrum of LOR, and also it could be determined in existence of the spectrum of LOR by different methods including absorption correction method (AC) at 256.8 nm and 280 nm, dual wavelength method (DW) at 254 nm and 273 nm, induced dual-wavelength method (IDW) at 230 nm and 263 nm, and ratio difference method (RD) at 256.8 nm and 270 nm. Loratadine (LOR) in the binary mixture could be determined either by direct analysis at 280 nm without any contribution from the spectrum of PSE or through its recovered spectrum of zero-order absorption via constant multiplication method (CM) using plateau region (277-326 nm). Also, concurrent determination for PSE and LOR in their overlapped binary mixture could be achieved by applying induced amplitude modulation (IAM) method. Results: Specificity of the proposed spectrophotometric methods was examined by the analysis of prepared mixtures in laboratory and was applied successfully for pharmaceutical dosage form analysis which has the cited drugs without additive contribution. The proposed spectrophotometric methods were also validated as per the guidelines of ICH. Statistical comparison was performed between the obtained results with those from the official methods of the cited drugs, using one-way ANOVA, F test, and Student's t test, and the results exhibit insignificant difference concerning precision and accuracy. Conclusions: The previously proposed spectrophotometric methods could be easily used accurately and precisely for simultaneous determination of the studied binary mixture with simple manipulation procedures.

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“…This method [37] is an extension for amplitude modulation method (AM) and advanced amplitude modulation (AMM) [37].…”

Section: Theoretical Background Induced Amplitude Modulation Methods (mentioning

confidence: 99%

Section: For Determination Of Psementioning

confidence: 99%

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Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

et al. 2019

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“…This novel method [8] can be applied for a binary mixture of X and Y with severely overlapped zero order absorption spectra at two wavelengths λ1 and λ2, where the absorbance of the interfering substance at those two wavelengths aren't equal (absorbance difference does not equal zero), so the conventional dualwavelength method [9,10] cannot be applied. To cancel the effect of Y at the two selected wavelengths, the equality factor of pure Y at these wavelengths (FY) is calculated and consequently the absorbance difference between two selected wavelengths of the mixture spectra is directly proportional to the concentration of component X.…”

Section: Induced Dual Wavelength Methods (Idw)mentioning

confidence: 99%

Recent Development in Ultraviolet Spectrophotometry Through the Last Decade (2006–2016): A Review

Lotfy

Saleh

2016

Int J Pharm Pharm Sci

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<p>Several techniques have been proposed for treatment of spectrophotometric data, with the objective of extracting the largest amount of analytical information from spectra composed of unresolved bands. The instrumental development and analytical applications of UV regions absorption spectrophotometry produced in the last 10 y (since 2006) are reviewed. The methods were classified according to the spectra data used, including zero order absorption, derivative and ratio amplitudes. The proposed methods were applied to solve different complex pharmaceutical mixtures and the obtained results were accepted when compared to other reported methods. </p>

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“…While IRD method is a combination between induced dualwavelength [18] and amplitude modulation theory. All what it need is the extension of one of the three drugs over the other two as summarized briefly.…”

Section: Theoretical Backgroundmentioning

confidence: 99%

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

Mohamed

Lotfy

Hegazy

et al. 2017

Chemistry Central Journal

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BackgroundAnalysis of complex mixture containing three or more components represented a challenge for analysts. New smart spectrophotometric methods have been recently evolved with no limitation. A study of different novel and smart spectrophotometric techniques for resolution of severely overlapping spectra were presented in this work utilizing isosbestic points present in different absorption spectra, normalized spectra as a divisor and dual wavelengths. A quaternary mixture of drotaverine (DRO), caffeine (CAF), paracetamol (PCT) and para-aminophenol (PAP) was taken as an example for application of the proposed techniques without any separation steps. The adopted techniques adopted of successive and progressive steps manipulating zero /or ratio /or derivative spectra. The proposed techniques includes eight novel and simple methods namely direct spectrophotometry after applying derivative transformation (DT) via multiplying by a decoding spectrum, spectrum subtraction (SS), advanced absorbance subtraction (AAS), advanced amplitude modulation (AAM), simultaneous derivative ratio (S1DD), advanced ratio difference (ARD), induced ratio difference (IRD) and finally double divisor–ratio difference-dual wavelength (DD-RD-DW) methods.ResultsThe proposed methods were assessed by analyzing synthetic mixtures of the studied drugs. They were also successfully applied to commercial pharmaceutical formulations without interference from other dosage form additives. The methods were validated according to the ICH guidelines, accuracy, precision, repeatability, were found to be within the acceptable limits.ConclusionThe proposed procedures are accurate, simple and reproducible and yet economic. They are also sensitive and selective and could be used for routine analysis of complex most of the binary, ternary and quaternary mixtures and even more complex mixtures.

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Novel two wavelength spectrophotometric methods for simultaneous determination of binary mixtures with severely overlapping spectra

Cited by 37 publications

References 35 publications

Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

Spectral analysis of overlapped absorption bands of binary mixtures—an application on combination of pseudoephedrine sulphate and loratadine mixture

Recent Development in Ultraviolet Spectrophotometry Through the Last Decade (2006–2016): A Review

Different applications of isosbestic points, normalized spectra and dual wavelength as powerful tools for resolution of multicomponent mixtures with severely overlapping spectra

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