Novel turn-on fluorescent biosensors for selective detection of cellular Fe3+ in lysosomes: Thiophene as a selectivity-tuning handle for Fe3+ sensors

Lim, Bumhee; Baek, Byungyeob; Jang, Kyungkuk; Lee, Na Keum; Lee, Ji Hye; Lee, Yeongcheol; Kim, Jin-Woo; Kang, San Won; Park, Jae-Hyun; Kim, Suzi; Kang, Nae Won; Hong, Suckchang; Kim, Dae Duk; Kim, Ikyon; Hwang, Hyonseok; Lee, Jeeyeon

doi:10.1016/j.dyepig.2019.05.008

Cited by 27 publications

(15 citation statements)

References 73 publications

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“…Nevertheless, the abnormality in Fe 3+ has been revealed to correlate with many diseases, such as anemia, Parkinson's syndrome and cancer [89,90]. There have been many reports for Fe 3+ detection with AIE probes [91][92][93][94].…”

Section: Fe 3+mentioning

confidence: 99%

“…Hence, combining cyano group and AIE fluorophore is an effective method to detecting Fe 3+ . Liu et al designed an AIE probe containing cyano groups and triphenylamine unit to detect Fe 3+ , CN − , and SO 3 2− [91].…”

Section: Fe 3+mentioning

confidence: 99%

“…Lee et al reported an iron-selective turn-on sensor IQ44 which shows high affinity and sensitivity towards Fe 3+ . By localized to lysosomes, IQ44 can imaging cellular Fe 3+ in lysosomes, and is promising for studying related biological processes (Figure 8a) [91].…”

Section: Fe 3+mentioning

confidence: 99%

“…IQ44 can imaging cellular Fe 3+ in lysosomes, and is promising for studying related biological processes (Figure 8a) [91]. [93].…”

Section: Fe 3+mentioning

confidence: 99%

“…Then, DSPE-PEG 2000 was reprecipitated with P2, forming lipid-P2 NPs [93]. (c) TPE-BIMEG [94] (Reproduced with permission from [91,93,94]).…”

Section: Fe 3+mentioning

confidence: 99%

See 4 more Smart Citations

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Zhong

Huang

et al. 2019

Molecules

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Metal ions play important roles in biological system. Approaches capable of selective and sensitive detection of metal ions in living biosystems provide in situ information and have attracted remarkable research attentions. Among these, fluorescence probes with aggregation-induced emission (AIE) behavior offer unique properties. A variety of AIE fluorogens (AIEgens) have been developed in the past decades for tracing metal ions. This review highlights recent advances (since 2015) in AIE-based sensors for detecting metal ions in biological systems. Major concerns will be devoted to the design principles, sensing performance, and bioimaging applications.

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Section: Fe 3+mentioning

confidence: 99%

Section: Fe 3+mentioning

confidence: 99%

Section: Fe 3+mentioning

confidence: 99%

“…IQ44 can imaging cellular Fe 3+ in lysosomes, and is promising for studying related biological processes (Figure 8a) [91]. [93].…”

Section: Fe 3+mentioning

confidence: 99%

“…Then, DSPE-PEG 2000 was reprecipitated with P2, forming lipid-P2 NPs [93]. (c) TPE-BIMEG [94] (Reproduced with permission from [91,93,94]).…”

Section: Fe 3+mentioning

confidence: 99%

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Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Zhong

Huang

et al. 2019

Molecules

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Synthesis of Poly‐Functionalized Indolizines via [5+1] Annulative Access to Pyridines

Joshi

Kim

2021

Adv Synth Catal

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Multi-functionalization of the pyridine motif of indolizine was achieved through [5 + 1] annulative construction of pyridine from 2-hydroxyacetophenone and pyrrole derivative in the presence of Cs 2 CO 3 . The reaction is proposed to take place via domino aldol-oxa Michael-Michael-elimination-oxidation procedure, leading to installation of three different functional groups at the C5, C6, and C7 positions of indolizines. Solvent (2-MeTHF) and the hydroxyl of 2-hydroxyacetophenones seemed to play crucial roles for this successful cyclization event. Further elaboration of the resulting scaffold and expansion of this protocol using other methyl ketones were demonstrated as well.

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Recent trends in molecular aggregates: An exploration of biomedicine

et al. 2022

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Molecular aggregates are receiving tremendous attention, demonstrating immense potential for biomedical applications in vitro and in vivo. For instance, the molecular aggregates of conventional fluorophores influence the electronic excitation states of the aggregates, causing characteristic photophysical property changes. A fundamental understanding of this classical relationship between molecular aggregate structures and photophysics has allowed for innovative biological applications. The chemical characteristics of drug molecules generally trigger the formation of colloidal aggregates, and this is considered detrimental to the drug discovery process. Furthermore, nano-sized supramolecular aggregates have been used in biomedical imaging and therapy owing to their optimal properties for in vivo utility, including enhanced cell permeability, passive tumor targeting, and convenient surface engineering. Herein, we provide an overview of the recent trends in molecular aggregates for biomedical applications. The changes in photophysical properties of conventional fluorophores and their biological applications are discussed, followed by the effects of conventional drug molecule-aggregates on drug discovery and therapeutics development. Recent trends in the investigation of biologically important analytes with aggregation-induced emission are discussed for conventional and unconventional fluorophores. Lastly, we discuss nano-sized supramolecular aggregates used in imaging and therapeutic purposes, with a focus on in vivo utilization.

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Novel turn-on fluorescent biosensors for selective detection of cellular Fe3+ in lysosomes: Thiophene as a selectivity-tuning handle for Fe3+ sensors

Cited by 27 publications

References 73 publications

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Recent Advances in AIEgens for Metal Ion Biosensing and Bioimaging

Synthesis of Poly‐Functionalized Indolizines via [5+1] Annulative Access to Pyridines

Recent trends in molecular aggregates: An exploration of biomedicine

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