2018
DOI: 10.1016/j.canlet.2018.06.017
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Novel tumor necrosis factor-α induced protein eight (TNFAIP8/TIPE) family: Functions and downstream targets involved in cancer progression

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Cited by 96 publications
(93 citation statements)
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“…A recent study has shown that TIPE2 overexpression could induce cell death and inhibit Ras‐mediated tumourigenesis in mice . In addition, deregulation of TIPE2 is found to promote the essential hallmarks of cancer such as survival, proliferation, invasion, migration, and metastasis . Similarly, our results showed that TIPE2 overexpression reduced the proliferation and viability, as well as decreased the migration and invasion capabilities of HR8348 and SW837 cells, whereas TIPE2 knockdown exhibited completely opposite effects, indicating that TIPE2 plays important roles in the growth, migration, and invasion of human rectal adenocarcinoma cells.…”
Section: Discussionsupporting
confidence: 73%
“…A recent study has shown that TIPE2 overexpression could induce cell death and inhibit Ras‐mediated tumourigenesis in mice . In addition, deregulation of TIPE2 is found to promote the essential hallmarks of cancer such as survival, proliferation, invasion, migration, and metastasis . Similarly, our results showed that TIPE2 overexpression reduced the proliferation and viability, as well as decreased the migration and invasion capabilities of HR8348 and SW837 cells, whereas TIPE2 knockdown exhibited completely opposite effects, indicating that TIPE2 plays important roles in the growth, migration, and invasion of human rectal adenocarcinoma cells.…”
Section: Discussionsupporting
confidence: 73%
“…TIPE was also the first discovered member and was originally identified as a partial cDNA clone in head and neck squamous cell carcinoma (HNSCC) cells in the late 1990s; these cells were derived from patients with metastatic radioresistant HNSCC [11,12]. TIPE is currently the most studied protein of the TNFAIP8 family, and related research has shown that it can regulate tumor apoptosis, tumorigenesis, progression, and prognosis [13,14]. In recent years, many studies have found that TIPE is highly expressed in cervical cancer [15], ovarian cancer [16,17], breast cancer [18,19], gastric cancer [20,21], non-small-cell lung cancer [22], pancreatic cancer [23], endometrial cancer [24] and papillary thyroid carcinoma [25].…”
Section: Introductionmentioning
confidence: 99%
“…Increasing lines of evidence suggest TIPE2, a newly identified protein, to play pivotal role in the modulation of tumorigenesis, inflammation, cell death, and other cellular activities. It has been found to be strongly associated with different cancers and several chronic diseases [19,59]. Therefore, the present study focused on deciphering the role of this protein in the pathogenesis of lung cancer, which would certainly help us to develop effective biomarkers and targets for the management of this cancer type.…”
Section: Discussionmentioning
confidence: 99%