Novel truncating germline variant reinforcesTINF2as a susceptibility gene for familial non-medullary thyroid cancer
Josep Oriola,
Orland Díez,
Mireia Mora
et al.
Abstract:BackgroundIt has long been observed that there are families in which non-medullary thyroid cancer (NMTC) occurs, but few syndromes and genes have been described to date. Proteins in the shelterin complex have been implied in cancer. Here, we have studied shelterin genes in families affected by NMTC (FNMTC).MethodsWe performed whole-exome sequencing (WES) in 10 affected individuals from four families with at least three affected members. Polymerase chain reaction (PCR) and Sanger sequencing were performed to se… Show more
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