Novel Triazolothiadiazole and Triazolothiadiazine Derivatives Containing Pyridine Moiety: Design, Synthesis, Bactericidal and Fungicidal Activities

Abdelhameed, Reda M.; El‐Sayed, Hassan A.; El‐Shahat, Mahmoud; El‐Sayed, Ahmed A.; Darwesh, Osama M.

doi:10.2174/1573407213666170127095158

Cited by 41 publications

(24 citation statements)

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“…The high differences in percentage and range of B. cereus may be due to the different formulas, different types of samples and different tests. New nontoxic and high stable bioactive materials were developed for controlling of the pathogens [ [39] , [40] , [41] ]. In addition to food grade natural materials may be will the best chance to control of the pathogens [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

Microbiological evaluation of infant foods quality and molecular detection of Bacillus cereus toxins relating genes

et al. 2018

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Section: Resultsmentioning

confidence: 99%

Microbiological evaluation of infant foods quality and molecular detection of Bacillus cereus toxins relating genes

et al. 2018

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“…Nowadays, the resistance mechanisms of almost pathogens are growing fast, because that the obtaining or research about new antimicrobial agents is considered the true way for controlling of these pathogens [5,9]. To achieve this goal, this study focused on isolation of new isolates from harsh environment.…”

Section: Antimicrobial Activitymentioning

confidence: 99%

“…New biotechnology deals to search about new isolates that have ability to grow and work at harsh conditions like extreme temperatures and pH values for using it in industrial, biotechnological and environmental applications [1][2][3]. Also, it goes up for solving problems by producing of producing nontraditional materials as antimicrobial agents [4][5][6], nanobiosynthesized metals like silver, copper and zinc [7,8] and biotechnological agents as bioactive materials [9][10][11][12]. Extremophile microorganisms have various adaptation mechanisms enabling them to thrive and produce secondary metabolites under harsh conditions [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Thermoflavimicrobium dichotomicum as a novel thermoalkaliphile for production of environmental and industrial enzymes

2019

Biointerface Res Appl Chem

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Thermoalkaliphilic actinomycetes enzymes have many important applications in many industrial, biotechnological and environmental aspects. So, the current study aimed to obtain the thermoalkali-enzymes producing actinomycetes. A novel thermoalkaliphilic actinomycete strain was isolated from Egyptian Siwa oasis and identified according to its morphological, physiological and biochemical characters as Thermoflavimicrobium dichotomicum. And then confirmed by phylogenetic analysis and the partial sequence was deposited in GenBank under accession number of KR011193 and name of Thermoflavimicrobium dichotomicum HwSw11. It could produce amylase, cellulase, lipase, pectinase and proteinase enzymes. Also, this strain exhibited anti-bacterial activities against P. aeruginosa and E. coli with inhibition zones of 14 and 20 mm, respectively. Consequently, it has antifungal activity against A. niger, A. flavus and Penicillium notatum with inhibition zones of 17, 14 and 14 mm, respectively. For that, it may be concluded that Thermoflavimicrobium dichotomicum HwSw11 as a novel thermoalkaliphile has a wide range of biological activities against a broad spectrum of pathogenic bacteria and fungi, in addition to produce many enzymes (amylase, cellulase, lipase, pectinase and proteinase). So, this isolate could be applied as manufactory for many industrial, biotechnological and environmental sectors.

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“…Researchers and scientists around the world work hard to develop new materials or derivatives for facing the pathogenic microbe's distribution in the environment [ 40 , 41 , 42 ]. These materials may be produced by microbial [ 43 ]or plant sources [ 44 ]as well as chemical synthesis [ 45 , 46 , 47 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents

Abdelhameed

Darwesh

El‐Shahat

2020

Heliyon

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Combination of arylidene hydrazinyl moiety with pyrido[2,3- d ]pyrimidin-4-one skeleton in compounds 7‒26 results in the output of unprecedented anti-microbial agents. Arylidene hydrazinyl based on Pyrido[2,3- d ]pyrimidin-4-one analoges 7‒26 prepared by the treatment of [2,3- d ]pyrimidin-4-ones 6a , b with various aromatic aldehydes. The antimicrobial action for recently synthesized compounds was considered towards gram positive bacterial species ( Staphylococcus aurous ATCC- 47077; Bacillus cereus ATCC-12228), gram negative bacterial species ( Escherichia coli ATCC-25922; Salmonella typhi ATCC-15566) and Candida albicans ATCC-10231 as fungal strains. The antimicrobial action expanded by expanding the electron donating group in position 2 and 5 for Pyrido[2,3- d ]pyrimidin-4-one core. Derivatives 13 , 14 , 15 , 16 and 12 ; individually appeared hopeful anti-microbial action towards all strains utilized with inhibition zone higher than that of standard reference drug with lowest MIC.

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Novel Triazolothiadiazole and Triazolothiadiazine Derivatives Containing Pyridine Moiety: Design, Synthesis, Bactericidal and Fungicidal Activities

Cited by 41 publications

References 0 publications

Microbiological evaluation of infant foods quality and molecular detection of Bacillus cereus toxins relating genes

Microbiological evaluation of infant foods quality and molecular detection of Bacillus cereus toxins relating genes

Thermoflavimicrobium dichotomicum as a novel thermoalkaliphile for production of environmental and industrial enzymes

Synthesis of arylidene hydrazinylpyrido[2,3-d]pyrimidin-4-ones as potent anti-microbial agents

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