Novel trialkylsilyl(germyl)-substituted thienyl- and furylbenzimidazoles and their N-substituted derivatives – synthesis, structure and cytotoxic activity

Игнатович, Л.; Старкова, О Я; Romanovs, Vitalijs; Sleiksha, Ilze; Шестакова, И.; Popelis, J.; Lukevics, É.

doi:10.1016/j.crci.2012.11.013

Cited by 7 publications

(4 citation statements)

References 38 publications

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“…The propargyl moiety was introduced in the 1,4-DHP molecule at position 1; better mitochondria-regulating properties were expected because this group was considered as essential in the antidepressant rasagiline molecule [20]. Moreover, N-alkylation of benzimidazole derivatives with propargyl halides led to more active compounds [25]. All 1,4-DHP derivatives were synthesised as N-H (N-unsubstituted) compounds (1, 3, 5, 7, 9, 11, 13, 15 and 17) and Npropargyl substituted compounds (2, 4, 6, 8, 10, 12, 14, 16 and 18).…”

Section: Chemistrymentioning

confidence: 99%

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

Ruciņš

Kaldre

Pajuste

et al. 2013

Comptes Rendus. Chimie

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Section: Chemistrymentioning

confidence: 99%

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

Ruciņš

Kaldre

Pajuste

et al. 2013

Comptes Rendus. Chimie

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“…Apart from the modification of natural compounds, GeR 3 moeity is introduced to various heterocyclic derivatives. Thus, a number of germylsubstituted hetarylbenzimidazoles (14) was synthesized, and showed high cytotoxicity on the cell lines MG-22A, HT-1080 and NIH 3T3 (Figure 16) [142]. A similar series of germylsubstituted pyrane-3-carbonitriles (15) also showed high cytotoxicity and the inhibition of matrix metalloproteinase (Figure 16) [143].…”

Section: Inorganic and Coordination Germanium Compoundsmentioning

confidence: 99%

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков

Popov

2023

Biomedicines

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and briefly suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and suppressed for a long time.

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“…Apart from the modification of natural compounds, GeR3 moeity is introduced into various heterocyclic derivatives. Thus, a number of germylsubstituted hetarylbenzimidazoles (14) was synthesized that showed high cytotoxicity on the cell lines MG-22A, HT-1080 and NIH 3T3 [147]. A similar series of germylsubstituted pyrane-3-carbonitriles (15) also showed high cytotoxicity and inhibition of matrix metalloproteinase [148].…”

Section: Other Germanium Compoundsmentioning

confidence: 99%

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Менчиков¹,

Popov²

2023

Preprint

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Germanium is an essential microelement, and its deficiency can result in numerous diseases, particularly oncogenic conditions. Consequently, water-soluble germanium compounds, including inorganic and coordination compounds, have attracted significant attention due to their biological activity. The review analyzes the primary research from the last decade related to the anticancer activity of germanium compounds. Furthermore, the review clarifies their actual toxicity, identifies errors and misconceptions that have contributed to the discrediting of their biological activity, and suggests a putative mechanism of germanium-mediated protection from oxidative stress. Finally, the review provides clarifications on the discovery history of water-soluble organic germanium compounds, which was distorted and hushed up for a long time.

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Novel trialkylsilyl(germyl)-substituted thienyl- and furylbenzimidazoles and their N-substituted derivatives – synthesis, structure and cytotoxic activity

Cited by 7 publications

References 38 publications

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

Synthesis and studies of calcium channel blocking and antioxidant activities of novel 4-pyridinium and/or N-propargyl substituted 1,4-dihydropyridine derivatives

Physiological Activity of Trace Element Germanium Including Anticancer Properties

Physiological Activity of Trace Element Germanium Including Anticancer Properties

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