“…The propargyl moiety was introduced in the 1,4-DHP molecule at position 1; better mitochondria-regulating properties were expected because this group was considered as essential in the antidepressant rasagiline molecule [20]. Moreover, N-alkylation of benzimidazole derivatives with propargyl halides led to more active compounds [25]. All 1,4-DHP derivatives were synthesised as N-H (N-unsubstituted) compounds (1, 3, 5, 7, 9, 11, 13, 15 and 17) and Npropargyl substituted compounds (2, 4, 6, 8, 10, 12, 14, 16 and 18).…”