Novel trends, challenges and new perspectives for enamel repair and regeneration to treat dental defects

Mohabatpour, Fatemeh; Chen, Daniel; Papagerakis, Silvana; Papagerakis, Pétros

doi:10.1039/d2bm00072e

Cited by 13 publications

(5 citation statements)

References 271 publications

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“…However, using excessively high speeds when polishing tooth surfaces with early carious lesions can lead to the loss of the outermost layer, resulting in the loss of enamel structure that could have been recovered through remineralization [36]. The loss of the outermost enamel layer that can be remineralized can accelerate the progression to a state of dental caries requiring restorative treatment [37]. Additionally, cracked teeth exhibited deep destruction patterns along the crack lines (Figure 7).…”

Section: Discussionmentioning

confidence: 99%

Effect of Rubber Cup Rotational Speeds during Tooth Polishing on Sound, Early Caries, and Cracked Tooth Surfaces

Chun,

Kim

2024

Applied Sciences

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High-speed rubber cup polishing can exacerbate tooth surface damage, especially when preexisting conditions such as early caries or cracks exist. This study aimed to quantify the extent of damage to sound teeth based on rotating rubber cup speed and assess the damage in relation to the tooth surface condition. Using a rubber cup, 36 sound teeth were polished at 100, 3000, and 10,000 rpm, and 24 teeth with early carious lesions and 24 cracked teeth were polished at 3000 and 10,000 rpm. Polishing was performed using a rubber cup and prophylaxis paste, applying an on–off method (3.0 N force for 3 s). Damage depth was quantified using a surface profilometer and examined using scanning electron microscopy. Polishing at 10,000 rpm caused significantly more damage to sound teeth than polishing at lower speeds (depth increase: 71.45 ± 15.12 µm at 100 rpm; 61.91 ± 17.82 µm at 3000 rpm; p < 0.001). Teeth with early carious lesions or cracks demonstrated more damage after polishing than sound teeth (p < 0.05). Therefore, the rotational speed of the rubber cup has a critical impact on the extent of enamel damage. Higher speeds can increase the damage depth in both sound and damaged tooth surfaces.

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Section: Discussionmentioning

confidence: 99%

Effect of Rubber Cup Rotational Speeds during Tooth Polishing on Sound, Early Caries, and Cracked Tooth Surfaces

Chun,

Kim

2024

Applied Sciences

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“…An example includes xylitol. Likewise, the activity of the trimetaphosphate ion (TMP) to enhance enamel and dentin remineralization is also currently an area of active research interest [ 65 ]. The following are calcium-based re-mineralizing agents: amorphous calcium phosphate (ACP) [ 66 ]; casein phosphopeptide (Recaldent) [ 67 ]; functionalized tricalcium phosphate (fTCP); particulate bioglass (NovaMin) [ 68 ]; nano-hydroxyapatite [ 69 ].…”

Section: Discussionmentioning

confidence: 99%

Assessing Fluorosis Incidence in Areas with Low Fluoride Content in the Drinking Water, Fluorotic Enamel Architecture, and Composition Alterations

Strużycka

Olszewska

Bogusławska-Kapała

et al. 2022

IJERPH

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There is currently no consensus among researchers on the optimal level of fluoride for human growth and health. As drinking water is not the sole source of fluoride for humans, and fluoride can be found in many food sources, this work aimed to determine the incidence and severity of dental fluorosis in Poland, in areas where a low fluoride content characterizes the drinking water, and to assess the impact of fluoride on the enamel composition and microstructure. The dental examination involved 696 patients (aged 15–25 years) who had since birth lived in areas where the fluoride concentration in drinking water did not exceed 0.25 mg/L. The severity of the condition was evaluated using the Dean’s Index. Both healthy teeth and teeth with varying degrees of fluorosis underwent laboratory tests designed to assess the total protein and fluoride content of the enamel. Protein amount was assessed spectrophotometrically while the level of fluoride ions was measured by DX-120 ion chromatography. The clinical study revealed 89 cases (12.8%) of dental fluorosis of varying severity. The enamel of teeth with mild and moderate fluorosis contained a significantly higher protein (p-value < 0.001 and 0.002, respectively) and fluoride level (p < 0.001) than those with no clinical signs of fluorosis. SEM images showed irregularities in the structure of the fluorotic enamel. An excessive fluoride level during amelogenesis leads to adverse changes in the chemical composition of tooth enamel and its structure. Moreover, dental fluorosis present in areas where drinking water is low in fluorides indicates a need to monitor the supply of fluoride from other possible sources, regardless of its content in the water.

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“…As a result of the biomimetic therapeutic approach it is possible to achieve not only maximum preservation of the intact enamel/dentin layer, but also to increase the lifetime of the restored area, as well as to ensure greater preservation of the tooth as a whole [3,4]. Therefore, a trend in modern dental material science is the development of a new class of hybrid biomaterials for hard tissue restoration with the above-mentioned properties [6][7][8]. To date, attempts have already been made to "regenerate" dental hard tissues, such as enamel, using synthesized mineral agents or specialized substances related to biogenic hard tissues [1,3,9,10].…”

Section: Introductionmentioning

confidence: 99%

A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level

Seredin,

Goloshchapov,

Buylov

et al. 2023

IJMS

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The creation of buffer (hybrid) layers that provide improved adhesion to two heterogeneous materials is a promising and high-priority research area in the field of dental materials science. In our work, using FTIR and Raman microspectroscopy at the submicron level in a system of dental composites/intact dental enamel, we assessed the molecular features of formation and chemically visualized the hybrid interface formed on the basis of a nature-like adhesive, polydopamine (PDA). It is shown that a homogeneous bioinspired PDA–hybrid interface with an increased content of O-Ca-O bonds can be created using traditional methods of dental tissue pretreatment (diamond micro drilling, acid etching), as well as the subsequent alkalinization procedure and the developed synthesis technology. The development of the proposed technology for accelerated deposition of PDA–hybrid layers, as well as the creation of self-assembled biomimetic nanocomposites with antibacterial properties, may in the future find clinical application for minimally invasive dental restoration procedures.

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Novel trends, challenges and new perspectives for enamel repair and regeneration to treat dental defects

Abstract: This paper presents new technologies and current challenges for enamel repair and the clinical aspects of enamel pathophysiology for the invention of new therapies.

Cited by 13 publications

References 271 publications

Effect of Rubber Cup Rotational Speeds during Tooth Polishing on Sound, Early Caries, and Cracked Tooth Surfaces

Effect of Rubber Cup Rotational Speeds during Tooth Polishing on Sound, Early Caries, and Cracked Tooth Surfaces

Assessing Fluorosis Incidence in Areas with Low Fluoride Content in the Drinking Water, Fluorotic Enamel Architecture, and Composition Alterations

A Study of the Peculiarities of the Formation of a Hybrid Interface Based on Polydopamine between Dental Tissues and Dental Composites, Using IR and Raman Microspectroscopy, at the Submicron Level

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