Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease

Sharma, Aruna; Menon, Preeti; Patnaik, Ranjana; Mureșanu, Dafin F.; Lafuente, José Vicente; Tian, Z. Ryan; Ozkızılcık, Asya; Castellani, Rudy J.; Mössler, Herbert; Sharma, Hari Shanker

doi:10.1016/bs.irn.2017.09.002

Cited by 25 publications

(1 citation statement)

References 118 publications

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“…Studies on the use of nanowires in the diagnosis and treatment of neurodegenerative diseases, especially AD and PD, continue. 120,121 5.11. Inorganic Nanoparticles.…”

Section: The Use Of Nanoscale Drug Delivery Systems In the Treatment ...mentioning

confidence: 99%

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Ozceylan,

Sezgin-Bayindir

2024

ACS Omega

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Neurodegenerative diseases, encompassing conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, prion disease, and Huntington's disease, present a growing health concern as human life expectancy increases. Despite this, effective treatments to halt disease progression remain elusive due to various factors, including challenges in drug delivery across physiological barriers like the blood−brain barrier and patient compliance issues leading to treatment discontinuation. In response, innovative treatment approaches leveraging noninvasive techniques with higher patient compliance are emerging as promising alternatives. This Review aims to synthesize current treatment options and the challenges encountered in managing neurodegenerative diseases, while also exploring innovative treatment modalities. Specifically, noninvasive strategies such as intranasal administration and nanosized drug delivery systems are gaining prominence for their potential to enhance treatment efficacy and patient adherence. Nanosized drug delivery systems, including liposomes, polymeric micelles, and nanoparticles, are evaluated within the context of outstanding studies. The advantages and disadvantages of these approaches are discussed, providing insights into their therapeutic potential and limitations. Through this comprehensive examination, this Review contributes to the ongoing discourse surrounding the development of effective treatments for neurodegenerative diseases.

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“…Studies on the use of nanowires in the diagnosis and treatment of neurodegenerative diseases, especially AD and PD, continue. 120,121 5.11. Inorganic Nanoparticles.…”

Section: The Use Of Nanoscale Drug Delivery Systems In the Treatment ...mentioning

confidence: 99%

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Ozceylan,

Sezgin-Bayindir

2024

ACS Omega

View full text Add to dashboard Cite

show abstract

Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer’s Disease Brain Pathology Exacerbated by Sleep Deprivation

Sharma¹,

Feng²,

Mureșanu³

et al. 2023

Advances in Neurobiology

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Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson’s Disease

Sharma¹,

Mureșanu²,

Feng³

et al. 2023

Advances in Neurobiology

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Novel Treatment Strategies Using TiO2-Nanowired Delivery of Histaminergic Drugs and Antibodies to Tau With Cerebrolysin for Superior Neuroprotection in the Pathophysiology of Alzheimer's Disease

Cited by 25 publications

References 118 publications

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Nanowired Delivery of Cerebrolysin Together with Antibodies to Amyloid Beta Peptide, Phosphorylated Tau, and Tumor Necrosis Factor Alpha Induces Superior Neuroprotection in Alzheimer’s Disease Brain Pathology Exacerbated by Sleep Deprivation

Nanodelivery of Histamine H3/H4 Receptor Modulators BF-2649 and Clobenpropit with Antibodies to Amyloid Beta Peptide in Combination with Alpha Synuclein Reduces Brain Pathology in Parkinson’s Disease

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