Novel Treatment for Hard-to-Heal Chronic Plantar Ulcers in Hansen’s Disease

Upadya, Gatha M; Govindarajan, Srinidhi

doi:10.7860/jcdr/2019/39777.12728

Cited by 2 publications

(3 citation statements)

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“…Hansen's disease (HD), renamed from leprosy, requires particular attention in the treatment of wounds due to impairment of wound healing process leading to chronic wounds which can further result in severe ulceration and an uncoordinated healing process. HD wounds, classified as non-healing wounds are difficult to manage causing disability of the patient and costs of treatment is very high [21]. HD wounds are unrecognized clinical problems [22] associated with several comorbidities [23].…”

Section: Resultsmentioning

confidence: 99%

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Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study

Babu

Srinivasan

Dhandapani³

et al. 2021

JPRI

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Aims: Natural biomaterials are more suitable than synthetic biomaterials for in vivo applications for treating damaged tissues. Collagen and chitosan are abundantly available natural biomaterials for wound dressings for tissue/wound repair. In this context, collagen-chitosan composite powder has been used to treat chronic wounds in Hansen disease (HD) patients. Place and Duration of Study: CSIR Central Leather Research Institute, Sardar Patel Road, Adyar, Chennai 600021, Southern Railway Headquarters Hospital, Constable Road, Ayanavaram, Chennai 600023, and Gremaltes Hospital, India between June 2013 and July 2020. Methodology: Collagen extracted from bovine rumen, a waste product of meat industry, and a commercially available chitosan were prepared as a composite powder (COL/CS) and applied to chronic wounds in HD patients after debridement and the wound contours were measured by planimetry. Biochemical parameters in blood samples were periodically assessed. Histopathology of wound tissue with Hematoxylin and Eosin and Masson’s Trichrome staining was studied. Matrix Metalloproteinase-9 (MMP9) levels before and after treatment were estimated. Results: Wound healing of 64.2% was obtained with COL/CS treatment and formation of granulation cells was observed early. Hemogram studies have been reported in a regression model with 95% confidence intervals. Histopathology revealed dense collagen fibres and continuity of sub-epithelial layer on 8th day. MMP-9 levels showed collagen integrity after treatment. Conclusion: The novel biocompatible, biodegradable COL/CS wound dressing is a promising biomaterial for management of chronic wounds in Hansen disease patients.

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Section: Resultsmentioning

confidence: 99%

“…The size of the control wound reduced to 1.54cm Measurement of wound size is a very important factor in the process of wound healing. Chronic plantar ulcers are a manifestation of Hansen's disease and are hard-to heal wounds [21]. In such patients, the demand for new and efficient wound dressings seems to be critical.…”

Section: Wound Healing Studymentioning

confidence: 99%

Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study

Babu

Srinivasan

Dhandapani³

et al. 2021

JPRI

View full text Add to dashboard Cite

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“…Wound dressings should be affordable and capable of reducing the healing time because long-term wound management could seriously affect the HD patients. Chronic ulcers in HD patients are an unrecognized clinical manifestation and need more attention on the treatment of HD ulcers [11,12]. Comorbid conditions are risk factors of delayed healing of plantar ulcers in HD patients [13].…”

Section: Introductionmentioning

confidence: 99%

Wound healing and Metabolite Profiling in Collagen-Chitosan Biomaterial-treated Chronic Wounds of Hansen’s Disease Patients

Babu

Srinivasan

Dhandapani³

et al. 2021

JPRI

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Aims: Impaired wound healing causes chronic ulcers in Hansen’s disease (HD) patients which are an unrecognized clinical manifestation and requires utmost care and attention for wound management. Collagen and chitosan biopolymers when synergistically combined produce a biologically active biomaterial for wound dressings. Hence, the aim was to prepare a collagen/chitosan (COL/CS) composite and characterize for wound healing potential in HD patients. Place and Duration of Study: CSIR-Central Leather Research Institute, Sardar Patel Road, Adyar, Chennai 600021, Southern Railway Headquarters Hospital, Constable Road, Ayanavaram, Chennai 600023, and Gremaltes Hospital, India between June 2013 and July 2020. Methodology: The HD wounds were measured by Planimetry in square cm and were also assessed for morphological structure of epidermis and collagen fiber arrangement by High Resolution- Scanning electron microscopy (HR-SEM). Proton Nuclear magnetic resonance spectroscopy (1H-NMR) for metabolite identification was studied in blood plasma samples of unwounded, untreated and treated HD patients Results: Size D (wound size on day of discharge) of the wounds were appreciably lower than Size 0 (wound size before biomaterial treatment) demonstrating efficient wound healing by the biomaterial. The morphological structure of the HD wounds showed healthy epidermal layer and thick fibers of collagen matrix in the treated wounds when compared to the controls. Key metabolites of metabolic pathways such as TCA cycle, creatine cycle and protein metabolism were identified by 1H-NMR spectroscopy Conclusion: The COL/CS wound dressing is a promising biomaterial for management of chronic wounds in Hansen’s disease.

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Novel Treatment for Hard-to-Heal Chronic Plantar Ulcers in Hansen’s Disease

Cited by 2 publications

References 0 publications

Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study

Collagen-Chitosan Composite Powder as a Novel Biomaterial for Chronic Wounds in Hansen Disease-A Clinical Study

Wound healing and Metabolite Profiling in Collagen-Chitosan Biomaterial-treated Chronic Wounds of Hansen’s Disease Patients

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