Novel transdermal photodynamic therapy using ATX-S10·Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice

Miyazawa, Shinichi; Nishida, Keiichiro; Komiyama, Takamitsu; Nakae, Yoshinori; Takeda, Ken; Yorimitsu, Masanori; Kitamura, Ai; Kunisada, Toshiyuki; Ohtsuka, Aiji; Inoue, Hajime

doi:10.1007/s00296-005-0052-9

Cited by 15 publications

(7 citation statements)

References 37 publications

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“…Antileukoproteinase, an inhibitor of neutrophil protease, completely abolished the disease [73] by inhibiting leukocyte attachment to the synovial endothelium [74], but the disease modifying anti-rheumatic drug methotrexate did not [75]. Transdermal photodynamic therapy reduced the clinical arthritis and synovial inflammation in CAIA [76]. …”

Section: Collagen Antibody-induced Arthritismentioning

confidence: 99%

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2006

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During the development of rheumatoid arthritis (RA) autoantibodies to IgG-Fc, citrullinated proteins, collagen type II (CII), glucose 6 phosphoisomerase (G6PI) and some other self-antigens appear. Of these, a pathogenic effect of the anti-CII and anti-G6PI antibodies is well demonstrated using animal models. These new antibody mediated arthritis models have proven to be very useful for studies involved in understanding the molecular pathways of the induction of arthritis in joints. Both the complement and FcγR systems have been found to play essential roles. Neutrophils and macrophages are important inflammatory cells and the secretion of tumour necrosis factor-α and IL-1β is pathogenic. The identification of the genetic polymorphisms predisposing to arthritis is important for understanding the complexity of arthritis. Disease mechanisms and gene regions studied using the two antibody-induced arthritis mouse models (collagen antibody-induced arthritis and serum transfer-induced arthritis) are compared and discussed for their relevance in RA pathogenesis. IntroductionBoth genetic and environmental factors interact and contribute to the development of autoimmune diseases. One such disease debilitating joint architecture is rheumatoid arthritis (RA). Arthritis in the joint involves a multicellular inflammatory process, including infiltration of lymphocytes and granulocytes into the articular cartilage, proliferation of synovial fibroblasts and macrophages and neovascularization of the synovial lining surrounding the joints. This proliferative process not only induces swelling, erythema, and pain in multiple joints but also progresses to joint destruction and causes loss of bone density and architecture. Many cellular components (macrophages, dendritic cells, fibroblast-like synoviocytes, mast cells, eosinophils, neutrophils, T cells and B cells), cell surface molecules (adhesion molecules, integrins), signaling components (ZAP70, PTPN22, JAK, mitogen activated protein kinase and Stat1) and humoral mediators (antibodies, cytokines, chemokines, metalloproteinases, serine proteases and aggrecanases) interact and aid in the disease progression, leading to digestion of extracelluar matrix and destruction of articular structures.The importance of B cells in RA pathogenesis stems not only from the original finding of high titers of rheumatoid factors (RFs), but also from the observation that arthritis is mediated in experimental animals via B cells and anti-collagen type II (anti-CII) antibodies [1][2][3][4][5]. Interest in studying the role of B cells in arthritis has returned as a result of successful anti-CD20 therapy [6][7][8]. In addition, the two widely used mouse models of antibody-initiated arthritis, collagen antibodyinduced arthritis (CAIA; induced with anti-CII antibodies) and the newly developed serum transfer-induced arthritis (STIA; induced with anti-glucose 6 phosphoisomerase (anti-G6PI) anti-sera) have been better characterized. B cells can contribute to the disease pathogenesis as antigen presenti...

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Section: Collagen Antibody-induced Arthritismentioning

confidence: 99%

Untitled

2006

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“…Selective photodynamic destruction of inflamed synovia has already been introduced as a new synovectomy modality, but only with intraarticular irradiation procedures [7,15,26,27] or with PSs which have absorption maxima lower than 700 nm [16,28]. With the availability of second generation PSs with near infra-red absorption maxima, it is possible to resolve deeper tissue structures because long wavelength photons are able to penetrate deeper into tissues [21,24].…”

Section: Discussionmentioning

confidence: 99%

“…Subsequent activation of the PS by means of monochromatic light at the appropriate wavelength (laser) leads to the generation of radical oxygen species (ROS) with cytotoxic effects [9][10][11][12][13]. PDT has been shown to be a highly selective and minimally invasive technique for ablating the synovial membrane [14][15][16]. As PS does not accumulate in bradytrophic structures such as cartilage, menisci, and ligaments, the effects of PDT are maximized in the inflamed synovia [17].…”

Section: Introductionmentioning

confidence: 99%

Transdermal photodynamic therapy—a treatment option for rheumatic destruction of small joints?

et al. 2006

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“…Each limb was graded individually on a scale of 0-4, where 0 = normal, 1 = mild but definite redness and swelling of the ankles or redness and swelling of any degree in any single digit, 2 = moderate to severe redness and swelling of the ankles, 3 = redness and swelling of the entire foot including the digits, and 4 = maximally inflamed limb, with involvement of multiple joints. The maximum cumulative clinical arthritis score for each mouse was 16 [12]. All animal experiments were approved by the Institutional Animal Care and Use Committee of Josai University.…”

Section: Animals and Treatmentsmentioning

confidence: 99%

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

et al. 2009

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Salacia reticulata is a native plant of Sri Lanka. In the traditional medicine of Sri Lanka and India, Salacia reticulata bark is considered orally effective in the treatment of rheumatism, gonorrhea, skin disease and diabetes. We have investigated, both in vivo and in vitro, whether the leaf of Salacia reticulata (SRL) can ameliorate collagen antibody-induced arthritis (CAIA) in mice as the rheumatoid arthritis (RA) model. The mice were fed a lard containing chow diet (AIN-93G) or the same diet containing 1% (w/w) SRL powder. All mice were bred for 23 days. On day 7 or 14 after LPS injection, mice were killed, and tissue and blood samples were collected. Histological analysis was performed, and serum levels of inflammatory mediators and the mRNA levels of inflammation-related genes and osteoclast-related genes were measured. SRL treatment ameliorated the rapid initial paw swelling, inflammatory cells infiltration, skeletal tissues damage, osteoclast activation and the mRNA levels for osteoclast-related genes compared with the CAIA mice. However, the serum and mRNA levels of inflammatory mediators did not differ between the CAIA mice and the SRL-treated mice. SRL might reduce the inflammatory cells induction and skeletal tissue degradation by CAIA by the regulating osteoclastogenesis.

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Novel transdermal photodynamic therapy using ATX-S10·Na(II) induces apoptosis of synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice

Cited by 15 publications

References 37 publications

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Transdermal photodynamic therapy—a treatment option for rheumatic destruction of small joints?

Effects of the Sri Lankan medicinal plant, Salacia reticulata, in rheumatoid arthritis

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