Novel Toll-Like Receptor 9 Agonist Derived from &lt;b&gt;&lt;i&gt;Cryptococcus neoformans&lt;/i&gt;&lt;/b&gt; Attenuates Allergic Inflammation Leading to Asthma Onset in Mice

Dobashi-Okuyama, Kaori; Kawakami, Kazuyoshi; Miyasaka, Tomomitsu; Sato, Ko; Kawakami, Katsuhiro; Masuda, Chiaki; Suzuki, Syugo; Kasamatsu, Jun; Yamamoto, Hiromitsu; Tanno, Daiki; Emi, Kazuyuki; Tanno, Hiromasa; Kawano, Tasuku; Takayanagi, Motowo; Takahashi, Tomoko; Ohno, Isao

doi:10.1159/000508535

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Nucleic acids of pathogens induce an inflammatory response. Oligodeoxynucleotide (ODN) derived from C. deneoformans (termed ODN112), which contains a cytosineguanine (CG) sequence but not canonical CpG motifs, is a potential Th1-inducing adjuvant during Th2 cell differentiation 59) .…”

Section: Cell Wallmentioning

confidence: 99%

PAMPs and Host Immune Response in Cryptococcal Infection

Sato

Kawakami

2022

Medical Mycology Journal

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Cryptococcus spp. are yeast-type opportunistic fungal pathogens with thick polysaccharide capsules that infect the lungs via airborne routes and frequently cause fatal meningoencephalitis. The cellular immune mechanism plays a central role in controlling cryptococcal infection and is critically regulated by Th1-Th2 immune balance. Pathogens that have invaded the host are recognized by innate immune cells, and appropriate immune responses are initiated. Pathogen-associated molecular patterns (PAMPs) are recognized by macrophages and dendritic cells via pattern recognition receptors (PRRs), which trigger the inflammatory responses as the first line of host defense. Some PRRs, such as Toll-like receptors (TLRs), NOD-like receptors (NLRs), and C-type lectin receptors (CLRs), are involved in the recognition of cryptococcal components, such as glucuronoxylomannan (GXM), mannoproteins (MPs), and nucleic acids. However, some cryptococcal cell components suppress the host immune response. This review will highlight the cryptococcal components involved in host immune responses. Future research is expected to promote the understanding of the mechanism of host immune response to Cryptococcus, which will lead to the development of new vaccines and therapies for cryptococcal infection.

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Section: Cell Wallmentioning

confidence: 99%

PAMPs and Host Immune Response in Cryptococcal Infection

Sato

Kawakami

2022

Medical Mycology Journal

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“…Non-canonical CpG-ODN derived from the fungus Cryptococcus neoformans (ODN112) was previously shown to trigger in bone marrow-derived dendritic cells a strong TLR9-dependent IL-12p40 production [36]. A new study using ovalbumin (OVA)-induced asthma mouse model evidenced that ODN112, administrated during the OVA sensitization (OVA + Alum), could prevent the induction of the specific allergic response [37 ▪ ]. Methylated CpG motifs typically found in human genomic DNA are described as non-inflammatory molecules.…”

Section: Cpg Oligodeoxynucleotide As Adjuvant or Non-specific Treatmentmentioning

confidence: 99%

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy

Jacquet

2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewMolecular forms of allergen-specific immunotherapy (AIT) are continuously emerging to improve the efficacy of the treatment, to shorten the duration of protocols and to prevent any side effects. The present review covers the recent progress in the development of AIT based on nucleic acid encoding allergens or CpG oligodeoxynucleotides (CpG-ODN). Recent findingsTherapeutic vaccinations with plasmid deoxyribonucleic acid (DNA) encoding major shrimp Met e 1 or insect For t 2 allergen were effective for the treatment of food or insect bite allergy in respective animal models. DNA expressing hypoallergenic shrimp tropomyosin activated Foxp3 þ T regulatory (Treg) cells whereas DNA encoding For t 2 down-regulated the expression of pruritus-inducing IL-31. Coadministrations of major cat allergen Fel d 1 with high doses of CpG-ODN reduced Th2 airway inflammation through tolerance induction mediated by GATA3 þ Foxp3 hi Treg cells as well as early antiinflammatory TNF/TNFR2 signaling cascade. Non-canonical CpG-ODN derived from Cryptococcus neoformans as well as methylated CpG sites present in the genomic DNA from Bifidobacterium infantis mediated Th1 or Treg cell differentiation respectively. SummaryRecent studies on plasmid DNA encoding allergens evidenced their therapeutic potential for the treatment of food allergy and atopic dermatitis. Unmethylated or methylated CpG-ODNs were shown to activate dose-dependent Treg/Th1 responses. Large clinical trials need to be conducted to confirm these promising preclinical data. Moreover, tremendous success of messenger ribonucleic acid (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 must encourage as well the re-exploration of mRNA vaccine platform for innovative AIT.

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Novel Toll-Like Receptor 9 Agonist Derived from <b><i>Cryptococcus neoformans</i></b> Attenuates Allergic Inflammation Leading to Asthma Onset in Mice

Cited by 2 publications

References 48 publications

PAMPs and Host Immune Response in Cryptococcal Infection

PAMPs and Host Immune Response in Cryptococcal Infection

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy

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