Novel therapy for pediatric and adolescent kidney cancer

Walz, Amy L.; Fernandez, Conrad V.; Geller, James I.

doi:10.1007/s10555-019-09822-4

Cited by 14 publications

(7 citation statements)

References 116 publications

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“…Pek çok WT'de persistan embriyonik nefrojenik kalıntıların varlığı, normal gelişim sürecinde sapma ile tümör oluşumu arasındaki bağlantıyı destekleyen unsurlardandır. Günümüze dek, WT'ü etiyopatogenezinde etkili pek çok faktör bildirilmiştir (15)(16)(17)(18) . Ancak literatürde ERG veya ETS genlerinin WT etiyopatogenezindeki rolüne ilişkin çalışma bulunmamaktadır.…”

Section: Discussionunclassified

“…Ancak hala bazı histolojik ve moleküler özelliklere sahip olgularda, bilateral ve tekrarlayan hastalıklarda sağkalım oldukça kötüdür. Yüksek riskli olarak tanımlanan olgular, WT'li hastaların 1/4-1/5 kadarını oluşturmaktadır (17) . Çalışmamızda da literatürle uyumlu şekilde yüksek riskli hastalar tüm hastaların %20,8'ini oluşturmaktaydı ve bu hastaların tümü kaybedildi.…”

Section: Discussionunclassified

“…WT'nün tümorogenezi, farklı transkripsiyon faktörleri, protoonkojenler ve çeşitli büyüme faktörlerinin etkili olduğu bozulmuş bir nefrojenez olarak düşünülebilir (16) . Günümüzde interdisipliner tanı ve tedavi modaliteleriyle sağkalım oranları %90'lara ulaşmasına rağmen, bazı hastalar daha kısa sağkalım ve artmış relaps oranları göstermektedir (17,18) . ERG'nin çeşitli malignitelerin gelişimine katkısına dair çok sayıda çalışma bulunmaktadır.…”

Section: Introductionunclassified

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Evaluation of Immunhistochemical ERG Tissue Expression in Wilms Tumor

Dınız¹,

Birol²,

Öniz³

et al. 2020

BUCH

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Objective: The ETS-related gene (ERG) is an oncogene that encodes one of the erythroblast transformationspecific (ETS) transcription factors. Although there are many studies on their effects on the development of different malignancies, mainly prostate cancer, Ewing sarcoma and acute myeloid leukemia, its association with Wilms tumor has never been investigated. The aim of this study was to evaluate ERG tissue expression in Wilms tumors. Methods: ERG expression and its association with clinicopathological features were evaluated in tissue sections obtained from 53 children with Wilms tumors. Results: The mean age of the cases was 3.21±2 years. This series consisted of 25 boys (47.2%) and 28 girls (52.8%). The mean tumor size was 9.1±2.9 cm. The mean kidney weight was 474.5±310.7 g. Thirteen (24.5%) cases were in stage I, 20 (37.7%) in stage II, 7 (14%) in stage III and 6 (11.3%) in stage IV. Forty-two cases were alive (79.2%) and being followed up. The mean survival time was 65.3±40.2 (2-148) months. Nuclear ERG expression was detected in 21 (39.6%) cases. In 8 (15.1%) cases, ERG expression was limited to pure blastemal component. Eleven cases (20.8%) had ERG expression in blastemal and mesenchymal components. Two patients (3.8%), one of which with bilateral tumors, had diffuse nuclear ERG expression. There was no correlation between ERG expression and prognostic factors except tumor bilaterality. Conclusion: This study demonstrates that nuclear ERG expression is not related to the pathogenesis of Wilms tumor. Although there was no statistically significant p value; since ERG expression is more common in bilateral tumors, it is thought that ERG may have a supporting role in the development of WT.

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Section: Discussionunclassified

Section: Introductionunclassified

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Evaluation of Immunhistochemical ERG Tissue Expression in Wilms Tumor

Dınız¹,

Birol²,

Öniz³

et al. 2020

BUCH

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“…However, patients with SIOP stage I have an excellent survival. 6 , 40 A distinct chemotherapy resistance characterizes RTK. Young age often delays radiotherapy.…”

Section: Current Conventional Therapeutic Approaches In Extracranial Mrtmentioning

confidence: 99%

Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors

Nemes

Johann²,

Tüchert³

et al. 2022

CMAR

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“…Wilms tumor (WT) is a common abdominal tumor that accounts for more than 90% of all malignant renal tumors in children ( 1 – 3 ). The incidence of WT is approximately 1/10,000, and the tumor is known to be highly malignant, to grow fast, and to be prone to metastasis ( 4 – 8 ).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor

Liu

2022

Front. Oncol.

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Long noncoding RNAs (LncRNAs) are transcripts of nucleic acid sequences with a length of more than 200 bp, which have only partial coding capabilities. Recent studies have shown that lncRNAs located in the nucleus or cytoplasm can be used as gene expression regulatory elements due to their important regulatory effects in a variety of biological processes. Wilms tumor (WT) is a common abdominal tumor in children whose pathogenesis remains unclear. In recent years, many specifically expressed lncRNAs have been found in WT, which affect the occurrence and development of WT. At the same time, lncRNAs may have the capacity to become novel biomarkers for the diagnosis and prognosis of WT. This article reviews related research progress on the relationship between lncRNAs and WT, to provide a new direction for clinical diagnosis and treatment of WT.

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Novel therapy for pediatric and adolescent kidney cancer

Cited by 14 publications

References 116 publications

Evaluation of Immunhistochemical ERG Tissue Expression in Wilms Tumor

Evaluation of Immunhistochemical ERG Tissue Expression in Wilms Tumor

Current and Emerging Therapeutic Approaches for Extracranial Malignant Rhabdoid Tumors

The Emerging Landscape of Long Non-Coding RNAs in Wilms Tumor

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