Novel therapy for anaplastic thyroid carcinoma cells using an oncolytic vaccinia virus carrying the human sodium iodide symporter

An Oncolytic Vaccinia Virus Expressing the Human Sodium Iodine Symporter Prolongs Survival and Facilitates SPECT/CT Imaging in an Orthotopic Model of Malignant Pleural Mesothelioma

“…11 For these studies, we have modified the GLV-1h68 virus to carry hNIS, an imageable gene in an attempt to produce a therapeutic virus that we may be tracked by noninvasive imaging. We have previously published our success in utilizing this viral construct to both treat and provide real-time, non-invasive imaging of thyroid 12 , pancreatic 13 and triple negative breast cancer (TNBC) xenografts 14 . Most recently, we have demonstrated that GLV-1h153 can treat orthotopic TNBC underline tumors, prevent metastasis, and facilitate 131 I imaging of positive surgical margins after resection.…”

Immune responses in the thyroid cancer microenvironment: making immunotherapy a possible mission

“…OV-driven expression of NIS functions to concentrate radioisotopes with the additional advantages of specific targeting to cancer cells and immune stimulation by viral infection. Although mainly used to extend the use of radiovirotherapy to other solid cancers that do not have basal NIS expression, this method has been applied to thyroid cancers pre-clinically using a VACV carrying the human NIS (Gholami et al 2011). This strategy could be used clinically to reduce the off-target effects of standard-of-care radiotherapy and offer potential to eliminate drug-resistant metastases that mediate disease recurrence.…”

Anaplastic thyroid cancer – an overview of genetic variations and treatment modalities

“…Adeno 82,83 measles, 69 herpes simplex, 84,85 and vaccinia viruses 86,87 have been tested in vitro as well as in vivo in mouse explant models (Table 3). Conditionally replicative viruses include those that target cells with specific tumor suppressor pathways that have been [88][89][90] or are directed to negatively impact tumor growth such as targeting of angiogenesis.…”

“…Conditionally replicative viruses include those that target cells with specific tumor suppressor pathways that have been [88][89][90] or are directed to negatively impact tumor growth such as targeting of angiogenesis. 91 Non-replicative adenoviruses, used as vectors to replace tumor suppressor genes such as TP53, 92 TTF1,93 or to express genes with therapeutic potential such as the sodium iodide symporter (NIS) to enable dual targeting, 69,86 have also been evaluated ( Table 3). As single-modality therapy has been shown to have a limited effect on ATC, multimodality therapy has become the treatment of choice in recent years.…”

“…83 Oncolytic viruses (measles, vaccinia, and lentiviruses) expressing the NIS gene have been used to induce cell death as well as facilitate noninvasive imaging and radioiodine therapy. 69,86,94 Combinatorial therapeutic options using small molecule inhibitors such as paclitaxel, 84 bevacizumab, 89 gancliclovir, 95 and aurora kinase inhibitor AZD1152, 82 along with independent virus treatments, have also been evaluated preclinically.…”