Novel Therapies for Celiac Disease: A Clinical Review Article

Abstract

Celiac disease is emerging as an autoimmune disorder with increasing prevalence and incidence. The mean age of presentation is also increasing with the passage of time. The delay in diagnosis is partly attributable to the asymptomatic state in which most patients present. The diagnosis of the disease is primarily based on biopsy, but serology can also be included for possible screening purposes. Although the primary management strategy is to eliminate gluten from the diet of such patients; however, compliance with the diet and follow-up to detect healing might be difficult to maintain. Therefore, there is a need to investigate further management therapies that can be easily administered and monitored. The aim of the review is to discuss the epidemiology, clinical presentation, and novel therapies being investigated for celiac disease.

Vascular dysfunction and arterial hypertension in experimental celiac disease are mediated by gut-derived inflammation and oxidative stress

“…It can be assumed that longer duration of a gluten containing diet might worsen or prolong the cardiovascular impact. This study underlines not only the importance of the GFD in the treatment of the intestinal inflammation in CeD [ 47 ], but also for the suppression of remote inflammation, prominently of the cardiovascular system. The demonstrated proteomics data indicate that CeD-mediated inflammation in the intestine activates pro-inflammatory and counteracting anti-inflammatory pathways like CCL5 or IL-10.…”

From an understanding of etiopathogenesis to novel therapies—what is new in the treatment of celiac disease?

“…Technolodzy próbują też wykorzystać możliwości modyfikacji genetycznej to reduce immunotoxic components of gluten ( Ghazanfar et al, 2023 ; PubMed, 2024 ).…”

Assessment of Novel Proteins Triggering Celiac Disease via Docking-Based Approach

“…The treatment requires a strict lifelong gluten-free diet, eliminating wheat, barley, and rye from the patient’s diet. Adherence to this diet helps alleviate symptoms and promotes intestinal healing [ 16 ]. DQ2.5 is present in 25% of the world population, while DQ8.1 is present in 14% [ 17 ].…”