Novel Therapeutic Strategies and Combinations for HER2-Overexpressing Breast Cancer

Shabaya, S.; Nahta, Rita

doi:10.5772/20324

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Potential Mechanisms Of Igf-ir-mediated Trastuzumab Resis1

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2012

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“…Similarly, trastuzumab-resistant cells have been reported to show reduced p27kip1 [ 19 ] and increased cyclin E expression [ 37 ]. We showed that cells with acquired resistance to trastuzumab expressed reduced levels of p27kip1 protein [ 19 ] but not transcript [ 38 ]. Thus, downregulation of p27kip1 appears to occur through posttranslational mechanisms.…”

Section: Potential Mechanisms Of Igf-ir-mediated Trastuzumab Resismentioning

confidence: 99%

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

Nahta

2012

Chemotherapy Research and Practice

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Resistance to the HER2-targeted antibody trastuzumab is a major clinical concern in the treatment of HER2-overexpressing metastatic breast cancer. Increased expression or signaling of the insulin-like growth factor-I receptor (IGF-IR) has been reported in a subset of cell lines and clinical samples derived from trastuzumab-resistant breast cancers. Genetic and pharmacologic inhibition of IGF-IR signaling has been shown to improve response to trastuzumab in trastuzumab-naïve and trastuzumab-resistant models. In this paper, we will discuss the role of IGF-IR signaling in trastuzumab resistance. Further, we will discuss cotargeting IGF-IR and HER2 as a potential therapeutic strategy for HER2-over-expressing breast cancers that have progressed on trastuzumab treatment.

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Section: Potential Mechanisms Of Igf-ir-mediated Trastuzumab Resismentioning

confidence: 99%

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

Nahta

2012

Chemotherapy Research and Practice

View full text Add to dashboard Cite

show abstract

Novel Therapeutic Strategies and Combinations for HER2-Overexpressing Breast Cancer

Cited by 1 publication

References 69 publications

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

Deciphering the Role of Insulin-Like Growth Factor-I Receptor in Trastuzumab Resistance

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