Novel Therapeutic Approaches to Regulate Human Dihydrofolate Reductase Activity and Expression

Synthesis, antitumor activity, 3D-QSAR and molecular docking studies of new iodinated 4-(3H)-quinazolinones 3N-substituted

“…34 Principally, the overexpression of this protein is associated in HeLa cell lines. 35 The molecular docking studies were performed in the active site of DHFR. The results of induced-t molecular docking, considering exible residues from 6 Å of the best docked position, describe good correlation among experimental data and calculated values (Fig.…”