Keywords: Sewage sludge; enzymatic hydrolysis; heavy metals; Migration and transformation rule. Abstract. To understand the migration transformation rule of heavy metals in the process of extracting proteins from the sludge with enzymatic hydrolysis, this experiment studied the total amount of heavy metals in the sludge and the its morpHological change characteristics in the process, and the results showed that Zn, Pb and Cr in the sludge have potential risk of migration, among them, Zn has higher mobility; the Exchangeable Form and Carbonate-Bound Form of Cr and Pb in the sludge is mainly converted into the Organio-Bound Form and Residual Form in the process. This technology, which is used to extract protein of sludge by enzymatic hydrolysis can stabilize the heavy metals in some way.