Novel techniques of mechanical circulatory support for the right heart and Fontan circulation

Derk, Gwendolyn; Laks, Hillel; Biniwale, Reshma; Patel, Sumit; LaCruz, Kim De; Mazor, Einat; Williams, Ryan; Valdovinos, John; Levi, Daniel S.; Reardon, L.; Aboulhosn, Jamil

doi:10.1016/j.ijcard.2014.08.012

Cited by 38 publications

(28 citation statements)

References 34 publications

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“…75 Derk et al showed the feasibility of an axial pump (Jarvik 2000) to restore baseline hemodynamics and cardiac output in Fontan circulation in a pig model. 76 Rodefeld et al used a 3-dimensional computational model and showed that a single viscous Impella pump augments cavopulmonary blood flow and can be used as a bridge to recovery or transplant in patients with established univentricular Fontan circulation. 77 Our group is currently investigating a novel multilumen cannula to support the failing Fontan circulation by a computational fluid dynamic simulation model.…”

Section: Mcs In Achd Patients With Biventricular Physiologymentioning

confidence: 99%

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Haranal

Luo

Honjo

2020

Circ J

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Advances in surgical and medical care of children born with heart defects have led to the emergence of a unique subgroup of young adults known as adults with congenital heart disease (ACHD). Heart failure (HF) is the leading cause of mortality and morbidity in this subset. Management of HF is challenging in these patients owing to inherent structural variations with their associated physiological consequences. Heart transplantation is of limited utility in this group either because of donor shortage or associated comorbidities that make these patients ineligible for transplantation. Mechanical circulatory support (MCS) devices have evolved as an alternative treatment modality in supporting the failing myocardium of this population, but are often used less frequently than in those with a structurally normal heart because of the unique anatomical and physiological variations. These variations create a need to gather adequate knowledge on how best to support the hearts of ACHD patients in order to reduce mortality and morbidity. This review presents clinical experience with MCS in ACHD patients.

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Section: Mcs In Achd Patients With Biventricular Physiologymentioning

confidence: 99%

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Haranal

Luo

Honjo

2020

Circ J

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“…Although the pump is designed for the LV, it has been adapted for supporting the RV to promote biventricular support . Derk et al reported using the adult pump for pulmonary MCS in Yorkshire pigs with simulated Fontan physiology; a TCPC was not attempted. Systemic venous pressure increased and the arterial pressure and cardiac output dropped, but the pump was able to restore these parameters to baseline levels.…”

Section: Clinically Used Devicesmentioning

confidence: 99%

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

et al. 2016

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The use of mechanical circulatory support (MCS) devices is a viable therapeutic treatment option for patients with congestive heart failure. Ventricular assist devices, cavopulmonary assist devices, and total artificial heart pumps continue to gain acceptance as viable treatment strategies for both adults and pediatric patients as bridge-to-transplant, bridge-to-recovery, and longer-term circulatory support alternatives. We present a review of the current and future MCS devices for patients having congenital heart disease (CHD) with biventricular or univentricular circulations. Several devices that are specifically designed for patients with complex CHD are in the development pipeline undergoing rigorous animal testing as readiness experiments in preparation for future clinical trials. These advances in the development of new blood pumps for patients with CHD will address a significant unmet clinical need, as well as generally improve innovation of the current state of the art in MCS technology.

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“…Mechanical circulatory support was not designed for complex congenital cardiac conditions. However, there has been an increase in research efforts directed at understanding and developing a device that can safely be used in patients with a Fontan procedure [53–58]. There are potential advantages to restoring pulsatile flow to the lungs in this population.…”

Section: Assist Devicesmentioning

confidence: 99%

Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

Bradley

Hendrickson

Daniels

2015

Curr Treat Options Cardio Med

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Opinion statement Adults with complex congenital heart disease that resulted in a Fontan procedure frequently experience late cardiac failure. Increasingly, liver disease is recognized as an important complication of single-ventricle anatomy and Fontan physiology; however, there is no consensus regarding liver evaluation in this population. Here, we review what is known about liver disease in this unique group and propose screening and prevention measures. We also review controversial treatment areas including assist devices and transplantation, with a review of outcomes in isolated heart and combined heart-liver transplant.

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Novel techniques of mechanical circulatory support for the right heart and Fontan circulation

Cited by 38 publications

References 34 publications

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Mechanical Circulatory Support for Patients With Adult Congenital Heart Disease

Mechanical Circulatory Support Devices for Pediatric Patients With Congenital Heart Disease

Fontan Liver Disease: Review of an Emerging Epidemic and Management Options

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