“…Recently, fibrillar aggregates of Tau protein were purified from human postmortem brain from Alzheimer's, Pick's disease, and chronic traumatic encephalopathy patients, showing variations in Tau fibril conformations between diseases (Falcon et al, 2018;Falcon et al, 2019;Fitzpatrick et al, 2017), and these fibrils all differed from the in-vitro generated, heparin-induced tau fibrils . However, to our knowledge, purification of α-Syn fibrils from human brain of Parkinson's disease patients is more challenging.…”