Abstract:Treatment with 5-Aminolevulinic acid-mediated photodynamic therapy is a promising therapeutic option for various carcinomas. An appropriate photosensitizer for photodynamic therapy is protoporphyrin-IX (PpIX), a light sensitive metabolite of heme synthesis. Incorporation of iron into PpIX leading to heme is carried out by Ferrochelatase (FECH). Earlier, we described a significant down regulation of FECH mRNA-expression and enzyme activity in carcinoma cells leading to an endogenous accumulation of PpIX. How Pp… Show more
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