Novel synthetic method for the preparation of amphiphilic hyaluronan by means of aliphatic aromatic anhydrides

Preparation of arginine–glycine–aspartic acid-modified biopolymeric nanoparticles containing epigalloccatechin-3-gallate for targeting vascular endothelial cells to inhibit corneal neovascularization

“…The acetamido moiety of the N-acetyl-d-glucosamine residue of HA ( Figure 2B) was located at δ=1.9 ppm, as previously described. 18,23 Fingerprints of HA skeletal signals at δ=3.4-3.9 ppm were observed, and 2.075 ppm for CH 3 and anomeric resonance at 4.4-4.6 ppm 24 were also detected. The magnification of the bracket in Figure 2B represents the skeletal signal of HA in the HA-RGD pattern, which can also be traced.…”

Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications

“…15 For example, esterification of HA with fatty acid residues could be applied to prepare waterinsoluble fibers. 16 Good biocompatibility of this material was confirmed in vitro as this type of HA modification has been tested as a drug delivery carrier, 17 coating of luminescent upconverting nanoparticles, 18 non-adhesive thin-film for TE 19 or in vivo in a form of SPION-loaded carrier system. 20 However, the surface interaction of these fibers with cellular components was highly restricted.…”

“…Physical and chemical crosslinking or hydrophobization by hydrophobic moieties are among the favorites . For example, esterification of HA with fatty acid residues could be applied to prepare water‐insoluble fibers . Good biocompatibility of this material was confirmed in vitro as this type of HA modification has been tested as a drug delivery carrier, coating of luminescent upconverting nanoparticles, non‐adhesive thin‐film for TE or in vivo in a form of SPION‐loaded carrier system .…”

Oleyl-hyaluronan micelles loaded with upconverting nanoparticles for bio-imaging

“…Grafting hydrophobic moiety on a hydrophilic HA backbone produces an amphiphilic derivative, which can selfassemble in aqueous media. Resulting micelle-like structures contain hydrophobic domains into which hydrophobic drugs (Š mejkalová et al 2014a;Huerta-Angeles et al 2014) and/or nanoparticles (Š mejkalová et al 2014b;Zhang et al 2014) can be incorporated. Furthermore, HA possesses a high content of hydroxyl and carboxyl functional groups which can be used for conjugation with targeting molecules (Liu et al 2011Kim et al 2012).…”