Novel Synthesis of Pyridine-2(1H)-thiones: Reaction of Imino Esters with Cyanothioacetamide†

Synthesis of new 5‐arylazo‐3‐cyano‐4,6‐dimethyl‐2‐acetylchloridethiopyridine reactive disperse dyes and their applications in textile printing

“…In spite of a large number of reports on the utility of these compounds in the dye industry, to our knowledge, only a few of the corresponding pyridinethione derivatives have been reported. In continuation of our interest in the synthesis of arylazopyridine‐2(1H)‐thiones (Elgemeie and Fathy, 1995; Elgemeie and Hussain, 1994; Elgemeie et al , 1990, 1992, 1995, 1997, 2002). The present paper reports the synthesis of arylazo‐2‐acetylchloridethiopyridine derivatives as reactive‐disperse dyes.…”

Preparation and characterization of novel methylsulfanylpyrazolopyrimidine and methylsulfanylpyrazolotriazine azo dyes

“…Thus, the mass spectrum of 6v was compatible with the molecular formula C 20 H 18 N 6 O ðM þ ¼ 358Þ: 1 H NMR revealed a band at d 2.3 ppm assignable to CH 3 group, a band at d 3.4 ppm assignable to OCH 3 group, abroad singlet at d 6.2 ppm assignable to an amino group and a multiplet at 7.076-8.6 ppm assignable to the aromatic protons and pyrimidine H-2,3. During the course of our studies directed toward exploring the synthetic potential of ketene dithioacetals for synthesizing new classes of novel antimetabolites (Elgemeie et al, , 1996(Elgemeie et al, , 1997a(Elgemeie et al, , 1999(Elgemeie et al, , 2000. We have recently reported different successful approaches for synthesis of mercaptopurine and thioguanine analogues by the reaction of ketene dithioacetals with amino-and oxoazoles (Elgemeie et al, 1997b(Elgemeie et al, , c, 1998a.…”

New approach to the synthesis of 2-alkylsulfanyl-4,5,6-trimethylnicotinonitriles

“…Compounds of this series are also promising for designing drugs against Alzheimer's disease [4]. The synthesis of these compounds is preferably based on condensation of 1,3-dicarbonyl compounds with cyanoacetyl(thio)amide in the presence of bases [5][6][7][8].I, VI, Hlg = Cl, R = 2-МеОС 6 Н 4 NНСО (a); Br, 3-oxo-3Н-benzo[f]chromen-2-ylcarbonyl (b); Cl, thiazol-2-ylcarbamoyl (c); Cl, quinolin-8-ylcarbamoyl (d); Cl, Ph (e); I, Ме (f); I, n-Bu (g); I, Et (h); Br, 5,7-dibromo-3-oxo-3Н-benzo[f]chromen-2-ylcarbonyl (i); Br, 7-bromo-3-oxo-3Н-benzo[f]chromen-2-ylcarbonyl (j); Cl, СООН (k); Br, 4-NО 2 С 6 Н 4 СО (l); Br, 3,4-Cl 2 C 6 H 3 СО (m); Br, 3-BrC 6 H 4 CO (n); Br, 4-ClC 6 H 4 (o); Br, 4-BuC 6 H 4 СО (p); Cl, PhCH 2 ОСО (q); Br, 2,4-Me 2 C 6 H 3 (r); Cl, РrОСО (s); Br, 4-ClC 6 H 4 СО (t). CN S H 2 N CN…”

“…Compounds of this series are also promising for designing drugs against Alzheimer's disease [4]. The synthesis of these compounds is preferably based on condensation of 1,3-dicarbonyl compounds with cyanoacetyl(thio)amide in the presence of bases [5][6][7][8].…”