2019
DOI: 10.1016/j.tetlet.2019.04.053
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Novel synthesis of 1,4-thiazin-2-one O-(tert-butyl) oximes and benzo[b][1,4]thiazin-2-one O-(tert-butyl) oximes in the presence of K2CO3/SiO2

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“…While several assays that allow cysteine quantification have been reported, concomitant er determination is often not possible. 7 In our search for an optical probe that could overcome this limitation and allow quantification of the concentration and enantiomeric composition of cysteine in the presence of other amino acids including homocysteine, we found that phenacyl bromides have been used to synthesize unsaturated thiomorpholines 8 and other closely related pharmacophores with medicinal applications, Fig. 1.…”
mentioning
confidence: 99%
“…While several assays that allow cysteine quantification have been reported, concomitant er determination is often not possible. 7 In our search for an optical probe that could overcome this limitation and allow quantification of the concentration and enantiomeric composition of cysteine in the presence of other amino acids including homocysteine, we found that phenacyl bromides have been used to synthesize unsaturated thiomorpholines 8 and other closely related pharmacophores with medicinal applications, Fig. 1.…”
mentioning
confidence: 99%