Novel Synthesis, Characterization and Amoxicillin Release Study of pH-Sensitive Nanosilica/Poly(acrylic acid) Macroporous Hydrogel with High Swelling

Abstract

The effect of SiO2 nanoparticles on the formation of PAA (poly acrylic acid) gel structure was investigated with seeded emulsion polymerization method used to prepare SiO2/PAA nanoparticles. The morphologies of the nanocomposite nanoparticles were studied by transmission electron microscopy (TEM). Fourier-transform infrared (FTIR) spectroscopy results indicated that the PAA was chemically bonded to the surface of the SiO2 nanoparticles. Additionally, the resulting morphology of the nanocomposite nanoparticles confirmed the co-crosslinking role of the SiO2 nanoparticles in the formation of the 3D structure and hydrogel of PAA. SiO2/PAA nanocomposite hydrogels were synthesized by in situ solution polymerization with and without toluene. The morphology studies by field emission scanning electron microscopy (FESEM) showed that when the toluene was used as a pore forming agent in the polymerization process, a macroporous hydrogel structure was achieved. The pH-sensitive swelling behaviors of the nanocomposite hydrogels showed that the formation of pores in the gels structure was a dominant factor on the water absorption capacity. In the current research the absorption capacity was changed from about 500 to 4000 g water/g dry hydrogel. Finally, the macroporous nanocomposite hydrogel sample was tested as an amoxicillin release system in buffer solutions with pHs of 3, 7.2, and 9 at 37 °C. The results showed that the percentage cumulative release of amoxicillin from the hydrogels was higher in neutral and basic mediums than in the acidic medium and the amoxicillin release rate was decreased with increasing pH. Additionally, the release results were very similar to swelling results and hence amoxicillin release was a swelling controlled-release system.

Metal–Organic-Framework-Based Polymers for Effective Water Harvesting in Arid Areas

“…The peak at 1631 cm −1 is attributed to the C�O stretching of the acrylate groups. 17 These absorption bands in the P(AA-co-AM) qualitatively indicated the synthesis of copolymeric material based on PAM and PAA. Moreover, the absorption bands at 1257 cm −1 corresponding to C−N stretching were observed in the spectrum of UPHMs in the spectrum of functional polymeric monomers.…”

Tailoring the Swelling‐Shrinkable Behavior of Hydrogels for Biomedical Applications

“…On this basis, Sorkhabi et al constructed macroporous SiO 2 /PAA hydrogel with high SR (ranging from 500 to 4000) by in situ solution polymerization. [ 63 ] Thakur et al synthesized a itaconic acid grafted poly(acrylic acid‐co‐aniline) hydrogel with a high swelling percentage of 1755.3%. [ 64 ] Cėpla et al developed tens of nanometer‐thick hydrogel coatings containing methyl methacrylic acid, 2‐hydroxyethyl methacrylate (HEMA), and polyethylene glycol methacrylate (PEG 10 MA) monomers.…”

Antimicrobial Activities of Polyethylene Terephthalate-Waste-Derived Nanofibrous Membranes Decorated with Green Synthesized Ag Nanoparticles

“…Electrospinning offers many advantages, such as control over morphology, porosity, and composition [ 11 ], and it is a relatively simple and low-cost method to generate polymer nanofibers [ 12 ]. Up to now, several electrospun nanofibers have been fabricated from a wide variety of polymeric materials, including a polymer/inorganic nanocomposite based on both natural and synthetic polymers [ 13 , 14 , 15 ]. Nanosensors [ 16 , 17 ], controlled drug delivery systems [ 18 , 19 , 20 , 21 , 22 ], wound healing [ 23 , 24 , 25 ], tissue engineering [ 26 , 27 , 28 ], energy devices [ 29 ], filtration [ 30 , 31 ], distillation [ 32 , 33 ], and the determination of environmental pollutants and photocatalysts [ 34 , 35 ] are some of the applications of electrospun nanofibers and nanofibrous membranes.…”