Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting

Chen, Xiaoli; Lv, Haiyan; Ye, Min; Wang, Shengyu; Ni, Erru; Zeng, Fanwei; Cao, Chang; Luo, Fanghong; Yan, Jianghua

doi:10.1016/j.ijpharm.2012.01.043

Cited by 43 publications

(22 citation statements)

References 33 publications

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“…At low temperature, the line width is larger due to the particles dispersion in the direction of the anisotropy field, because as temperature decreases, isotropic magnetic moments are formed and causes a decrease in the line width 40,42 . To determine nanostructured material characteristics, without the need to make a detailed analysis along with the toxicity and biocompatibility tests at biological level, is enough to predict the potential application in molecular imaging and nanomedicine 43 . The biological part was not the objective of this work: however, because of the MNP properties and the character of biocompatible coating, the Figure 6.…”

mentioning

confidence: 99%

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

2014

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Nowadays the use of magnetic nanoparticles (MNP) in medical applications has exceeded expectations. In molecular imaging, MNP based on iron oxide coated with appropriated materials have several applications in vitro and in vivo studies. For applications in nanobiotechnology these MNP must present some characteristics such as size smaller than 100 nanometers, high magnetization values, among others. Therefore the MNP have physical and chemical properties that are specific to certain studies which must be characterized for quality control of the nanostructured material. This study presents the synthesis and characterization of MNP of magnetite (Fe 3 O 4 ) dispersible in water with perspectives in a wide range of biomedical applications. The characterization of the colloidal suspension based on MNP stated that the average diameter is (12.6±0.2) nm determined by Transmission Electron Microscopy where the MNP have the crystalline phase of magnetite (Fe 3 O 4 ) that was identified by Diffraction X-ray and confirmed by Mössbauer Spectroscopy. The blocking temperature of (89±1) K, Fe 3 O 4 MNP property, was determined from magnetic measurements based on the Zero Field Cooled and Field Cooled methods. The hysteresis loops were measured at different temperatures below and above blocking temperature. The magnetometry determined that the MNP showed superparamagnetic behavior confirmed by ferromagnetic resonance.

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confidence: 99%

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

2014

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“…The saturation magnetization of Fe 3 O 4 -CMC-genistein NPs was smaller than the value for the naked Fe 3 O 4 . The reduction of saturation magnetization showed that the Fe 3 O 4 MNPs are surrounded by organic materials [29]. Decrease of the mass saturation magnetization in the component maybe due to the surface functionalization, which caused the linkage between CMC and genistein onto the surface of Fe 3 O 4 nanoparticles [30].…”

Section: Discussionmentioning

confidence: 99%

Synthesizing efficacious genistein in conjugation with superparamagnetic Fe ₃ O ₄ decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma

2020

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Background: Genistein (C 15 H 10 O 5) is a soy isoflavone with anti-cancer properties such as inhibition of cell growth, proliferation and tumor invasion, but effective dosage against hematopoietic malignant cells was not in non-toxic range. This property cause to impede its usage as chemotherapeutic agent. Therefore, this hypothesis raised that synthesizing biocompatible nanoparticle could assist to prevail this struggle. Methods: Genistein covalently attached on Fe 3 O 4 nanoparticles decorated with carboxymethylated chitosan to fabricate Fe 3 O 4-CMC-genistein in alkaline circumstance. This obtained nanoparticles were evaluated by TEM, DLS, FTIR, XRD and VSM and its anti-cancer effect by growth rate and MTT assays as well as flow cytometer on ALL cancer cell lines. Results: Different evaluations indicated that the drug delivery vehicle had a mean diameter size around 12ƞm with well bounded components. This system presented high degree of magnetization and superparamagnetic properties as well as good water solubility. In comparison with pure genistein, significant growth inhibition on hematopoietic cancer cells in lower dose of genistein nano-conjugated onto Fe 3 O 4-CMC. It increased long lasting effect of genistein in cancer cells also. Conclusion: This delivery system for genistein could be remarkably promised and futuristic as biocompatible chemotherapeutic agent against hematopoietic malignant cells.

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“…Nevertheless, the magnetization curves of three samples were symmetrical and passed through the origin with no hysteresis, suggesting that the magnetic SPIO NPs and the consequent magnetic SPIO/Ca-ALG microspheres are typical paramagnetic materials. 36 The XRD patterns of SPIO NPs and two samples of SPIO/Ca-ALG microspheres are quite similar as shown in Figure 3F. The distinct diffraction peaks can be observed at 2θ of 29.84, 35.27, 43.04, 53.31, 56.82, and 62.56, those correspond to the crystal plane of (220), (311), (400), (422), (511), and (440) Figure 3 Magnetic properties of sPIO NPs and sPIO/ca-alg microspheres.…”

Section: Wang Et Almentioning

confidence: 99%

Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

Wang¹,

Liu²,

Yang³

et al. 2017

IJN

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Alginate microspheres loaded with superparamagnetic iron oxide nanoparticles (SPIO NPs) have been fabricated by a T-junction microfluidic device combined with an external ionic crosslinking. The obtained microspheres possess excellent visuality under magnetic resonance due to the presence of only 0.6 mg/mL SPIO NPs. The microspheres also show uniform size with narrow distribution and regular spherical shape characterized by optic microscope and environmental scanning electron microscope. Furthermore, dual drugs (5-fluorouracil and doxorubicin hydrochloride) have been loaded within the microspheres. The release behavior of dual drugs from the microspheres show typical sustained release profiles. As a novel embolic agent, such microspheres in blood vessels can be tracked by magnetic resonance scanner. Thus, the integration of embolotherapy, chemotherapy, and postoperative diagnosis can be realized.

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Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting

Cited by 43 publications

References 33 publications

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

Synthesizing efficacious genistein in conjugation with superparamagnetic Fe ₃ O ₄ decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma

Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

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Novel superparamagnetic iron oxide nanoparticles for tumor embolization application: Preparation, characterization and double targeting

Cited by 43 publications

References 33 publications

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

Synthesis and characterization of Fe3O4 nanoparticles with perspectives in biomedical applications

Synthesizing efficacious genistein in conjugation with superparamagnetic Fe 3 O 4 decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma

Magnetic alginate microspheres detected by MRI fabricated using microfluidic technique and release behavior of encapsulated dual drugs

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Synthesizing efficacious genistein in conjugation with superparamagnetic Fe ₃ O ₄ decorated with bio-compatible carboxymethylated chitosan against acute leukemia lymphoma