Novel sulphonamide-azaheterocycle conjugates and their anti-cancer, anti-inflammatory, anti-diabetic, anti-angiogenesis activity and molecular docking studies

Novel 2,4-Dichloro-5-sulfamoylbenzoic Acid Oxime Esters: First Studies as Potential Human Carbonic Anhydrase Inhibitors

“…Such a group is widely recognized for its capability to directly inhibit the catalytic action of CAs 10 through coordination of the zinc ion. 11,12 2,4-Dichloro-5-sulfamoylbenzoic acid (lasamide, 1) is the key intermediate for the synthesis of the diuretic furosemide and is a key precursor for experimental compounds with potential pharmaceutical applications, 13 thus including those acting as CAIs. 14,15 complexes with hCA I and hCA II and found to possess a potent inhibitory activity.…”

“…2,4-Dichloro-5-sulfamoylbenzoic acid (lasamide, 1 ) is the key intermediate for the synthesis of the diuretic furosemide and is a key precursor for experimental compounds with potential pharmaceutical applications, thus including those acting as CAIs. , Two lasamide salts are reported in complexes with hCA I and hCA II and found to possess a potent inhibitory activity . The Schiff base derivatives possess a broad spectrum of bioactivities, and various oxime derivatives containing the coumarin/sulfonamide moiety are also described as hCA IX and XII inhibitors. − …”