Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Trifonov, Lena; Chumin, Katerina; Gvirtz, Raanan; Afri, Michal; Korshin, É. E.; Cohen, Guy; Gruzman, Arie

doi:10.1016/j.mencom.2020.11.006

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…600 0.1 and transferred to a 96-well plate with or without Jojoba wax at 85 and 850 µg/mL. After 24 h, AlamarBlue (Resazurin) was added at a final concentration of 0.004%, and the fluorescence was determined (Excitation 550; Emission 590) as previously reported [ 45 ]. Zinc pyrithione (ZPT) at 100 µg/mL was used as a positive control.…”

Section: Methodsmentioning

confidence: 99%

Anti-Herpes Simplex 1 Activity of Simmondsia chinensis (Jojoba) Wax

et al. 2021

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Jojoba (Simmondsia chinensis (Link) Schneider) wax is used for various dermatological and pharmaceutical applications. Several reports have previously shown beneficial properties of Jojoba wax and extracts, including antimicrobial activity. The current research aimed to elucidate the impact of Jojoba wax on skin residential bacterial (Staphylococcus aureus and Staphylococcus epidermidis), fungal (Malassezia furfur), and virus infection (herpes simplex 1; HSV-1). First, the capacity of four commercial wax preparations to attenuate their growth was evaluated. The results suggest that the growth of Staphylococcus aureus, Staphylococcus epidermidis, and Malassezia furfur was unaffected by Jojoba in pharmacologically relevant concentrations. However, the wax significantly attenuated HSV-1 plaque formation. Next, a complete dose–response analysis of four different Jojoba varieties (Benzioni, Shiloah, Hatzerim, and Sheva) revealed a similar anti-viral effect with high potency (EC50 of 0.96 ± 0.4 µg/mL) that blocked HSV-1 plaque formation. The antiviral activity of the wax was also confirmed by real-time PCR, as well as viral protein expression by immunohistochemical staining. Chemical characterization of the fatty acid and fatty alcohol composition was performed, showing high similarity between the wax of the investigated varieties. Lastly, our results demonstrate that the observed effects are independent of simmondsin, repeatedly associated with the medicinal impact of Jojoba wax, and that Jojoba wax presence is required to gain protection against HSV-1 infection. Collectively, our results support the use of Jojoba wax against HSV-1 skin infections.

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Section: Methodsmentioning

confidence: 99%

Anti-Herpes Simplex 1 Activity of Simmondsia chinensis (Jojoba) Wax

et al. 2021

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“…Essential oil of A. annua, both in liquid and vapor phase, exhibited significant antimicrobial activity towards almost all the twenty strains of In a similar manner, Gruzman, Cohen et al described the 8-step synthesis of novel sulfamoylbenzoates and their subsequent inhibition of M. furfur growth. Methyl-3-bromo-2-nitro-5-(N-phenylsylfamoyl)benzoate SB-1 exhibited significant cytotoxic activity against M. furfur and was chosen as HIT for further development in the area of seborrheic dermatitis drugs (Figure 25) [123].…”

Section: Natural Compoundsmentioning

confidence: 99%

Anti-Malassezia Drug Candidates Based on Virulence Factors of Malassezia-Associated Diseases

Billamboz,

Jawhara

2023

Microorganisms

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Malassezia is a lipophilic unicellular fungus that is able, under specific conditions, to cause severe cutaneous and systemic diseases in predisposed subjects. This review is divided into two complementary parts. The first one discusses how virulence factors contribute to Malassezia pathogenesis that triggers skin diseases. These virulence factors include Malassezia cell wall resistance, lipases, phospholipases, acid sphingomyelinases, melanin, reactive oxygen species (ROS), indoles, hyphae formation, hydrophobicity, and biofilm formation. The second section describes active compounds directed specifically against identified virulence factors. Among the strategies for controlling Malassezia spread, this review discusses the development of aryl hydrocarbon receptor (AhR) antagonists, inhibition of secreted lipase, and fighting biofilms. Overall, this review offers an updated compilation of Malassezia species, including their virulence factors, potential therapeutic targets, and strategies for controlling their spread. It also provides an update on the most active compounds used to control Malassezia species.

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Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur

Cited by 2 publications

References 26 publications

Anti-Herpes Simplex 1 Activity of Simmondsia chinensis (Jojoba) Wax

Anti-Herpes Simplex 1 Activity of Simmondsia chinensis (Jojoba) Wax

Anti-Malassezia Drug Candidates Based on Virulence Factors of Malassezia-Associated Diseases

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