Novel strategy for mechanically tunable and bioactive metal implants

Jung, Hyun‐Do; Jang, Tae‐Sik; Wang, Lifeng; Kim, Hyoun Ee; Koh, Young Hag; Song, Juha

doi:10.1016/j.biomaterials.2014.10.027

Cited by 53 publications

(35 citation statements)

References 81 publications

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“…The high porosity and its interconnected structure facilitate transport of body fluids, benefit the spread of cells into the implant, and promote proliferation of bone tissue by increasing the contact area [11,23]. In the literature, different materials such as ceramics [16], polymers [32,52] or metallic scaffolds [22,51,56] have been proposed as porous implants to be used in bone tissue engineering. Ceramics or polymer scaffolds have been studied showing promising bioactive features; however, the low strength of polymers as well as brittleness of ceramics are notable drawbacks for bone implant applications.…”

Section: Introductionmentioning

confidence: 99%

Development of tantalum scaffold for orthopedic applications produced by space-holder method

et al. 2015

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a b s t r a c tIn the present study, production of tantalum porous scaffolds using the space holder technique was performed. The effect of size and content of sodium chloride particles, used as space holder, as well as compacting pressure on foam structure and mechanical properties have been investigated. The morphological characterization was carried out by means of scanning electron microscopy (SEM), mercury intrusion porosimetry (MIP) and micro-CT technique. The relationship between the elastic modulus and yield strength of the tantalum porous scaffold and the pore structure was evaluated. Space holder technique allows obtaining tantalum open-cell structure (70% of porosity) and modulus of elasticity similar to cancellous bone, with reproducible processability into three-dimensional structures and reasonable manufacturing costs.

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Section: Introductionmentioning

confidence: 99%

Development of tantalum scaffold for orthopedic applications produced by space-holder method

et al. 2015

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“…Accordingly, scaffolds with this structure would be useful for implanting at sites wherein early bone-to-implant contact is required. By tailoring the ratio between the two parts and their structural organization, the functional diversity of graded porous HA scaffolds can be expanded [45,46]. …”

Section: Resultsmentioning

confidence: 99%

The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

et al. 2017

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Porous hydroxyapatite (HA) scaffolds with porosity-graded structures were fabricated by sequential freeze-casting. The pore structures, compressive strengths, and biocompatibilities of the fabricated porous HA scaffolds were evaluated. The porosities of the inner and outer layers of the graded HA scaffolds were controlled by adjusting the initial HA contents of the casting slurries. The interface between the dense and porous parts was compact and tightly adherent. The porosity and compressive strengths of the scaffold were controlled by the relative thicknesses of the dense/porous parts. In addition, the porous HA scaffolds showed good biocompatibility in terms of preosteoblast cell attachment and proliferation. The results suggest that porous HA scaffolds with load-bearing parts have potential as bone grafts in hard-tissue engineering.

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“…The VH/rhBMP-2/n-MZS system gradually reduced the number of attached S. aureus with time (12,24,48, and 72 hours) ( Figure 6). However, the number of S. aureus with the VH/rhBMP-2/MZS gradually was reduced from 12 to 24 hours but increased from 48 to 72 hours.…”

Section: In Vitro Antibacterial Activitymentioning

confidence: 96%

“…10,11 Human bone morphogenetic protein-2 (rhBMP-2) with strong bone-inducing activity is considered to play important roles in bone regeneration. 12,13 However, the activity of rhBMP-2 is deteriorated by its short in vivo half-life, that is, rhBMP-2 can be quickly diluted and metabolized.…”

Section: Introductionmentioning

confidence: 99%

Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

Li¹,

Wu²,

Li³

et al. 2015

IJN

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Nanoporous magnesium–zinc–silicon (n-MZS) xerogels with a pore size ∼4 nm, a surface area of 718 cm 2 /g, and a pore volume of 1.24 cm 3 /g were synthesized by a sol–gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium–zinc–silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.

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Novel strategy for mechanically tunable and bioactive metal implants

Cited by 53 publications

References 81 publications

Development of tantalum scaffold for orthopedic applications produced by space-holder method

Development of tantalum scaffold for orthopedic applications produced by space-holder method

The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair

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Novel strategy for mechanically tunable and bioactive metal implants

Cited by 53 publications

References 81 publications

Development of tantalum scaffold for orthopedic applications produced by space-holder method

Development of tantalum scaffold for orthopedic applications produced by space-holder method

The Production of Porous Hydroxyapatite Scaffolds with Graded Porosity by Sequential Freeze-Casting

Sustained release of VH and rhBMP-2 from nanoporous magnesium&ndash;zinc&ndash;silicon xerogels for osteomyelitis treatment and bone repair

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Product

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Sustained release of VH and rhBMP-2 from nanoporous magnesium–zinc–silicon xerogels for osteomyelitis treatment and bone repair