Novel strategy for accurate tumor labeling: endogenous metabolic imaging through metabolic probes

Probing fluctuations in sulfur dioxide and viscosity levels during mitochondrial dysfunction using a dual-response fluorescent probe with good water solubility

“…Moreover, we evaluated the ability of probe MBI to image intracellular endogenous SO 2 , which is mainly generated by the enzymatic hydrolysis of Na 2 S 2 O 3 and GSH catalyzed by thiosulphate sulphurtransferase. 43 Compared with the control group, a significant increase in cyan fluorescence and a concomitant diminution of red fluorescence was noticed (Fig. 5), suggesting that the probe MBI can detect exogenous and endogenous SO 2 at the cellular level.…”

Nitrodopamine modified MnO2 NS-MoS2QDs hybrid nanocomposite for the extracellular and intracellular detection of glutathione

“…The findings of our extracellular GSH sensing by MnO 2 NS-MoS 2 QDs composite materials further encouraged us to study the detection of GSH in the intracellular medium. 74,75 To evaluate the practical functionality of the biosensor, we checked its cytotoxicity in human lung carcinoma (A549) cells by MTT assay before the detection of GSH in living cancer cells.…”

Prediction of Early Atherosclerotic Plaques Using a Sequence‐Activated Fluorescence Probe for the Simultaneous Detection of γ‐Glutamyl Transpeptidase and Hypobromous Acid

“…In addition, γ-glutamyl transpeptidase (GGT) is a cell mem-brane-localized glutathione (GSH)-hydrolysed protein that is involved in GSH transmembrane transport. [11] At the position of an atherosclerosis plaque, large amounts of GSH need to be synthesized within the cell to resist oxidative stress, resulting in an increase in GGT activity. [12] Simultaneously, GGT involves in hydrolysing extracellular GSH to cysteinylglycine (CysÀ Gly), and CysÀ Gly is a stronger reducing agent that is responsible for promoting the oxidation of low-density lipoproteins (LDL) to oxidized LDL (ox-LDL) outside the cell.…”