Novel strategies for the discovery of plant-derived anticancer agents

Kinghorn, A. D.; Farnsworth, Norman R.; Soejarto, Djaja D.; Cordell, Geoffrey A.; Pezzuto, J. M.; Udeani, George; Wani, Mansukh C.; Wall, Monroe E.; Navarro, Hilario; Kramer, Robert A.; Menendez, A. T.; Fairchild, Craig R.; Lane, Kate; Forenza, Salvatore; Vyas, D. M.; Lam, K. S.; Shu, Yue‐Zhong

doi:10.1351/pac199971091611

Cited by 101 publications

(92 citation statements)

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“…The need to develop more effective and less toxic anticancer drugs has prompted researchers to explore new sources of pharmacologically active compounds. Natural products have long been used to prevent and treat diseases, including cancers, and might be good candidates to develop anticancer drugs (Kinghorn et al, 1999). Plants have substantial potential to discover active anticancer compounds as most chemotherapeutic drugs, like taxol and vincristin, were already isolated from plants (Pezzuto et al, 1997).…”

Section: Resultsmentioning

confidence: 99%

Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: a Step Toward New Anticancer Agents?

Yıldız¹,

Bozcu²,

Tokgün³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Cyclamen coum is a traditional medicinal plant in the Turkey. Its anticancer properties and whether cyclamen extract induces any cytotoxicity in solid cancer cell lines have not been thoroughly investigated previously. Therefore we examined cytotoxic effects on cervical cells; HeLa and non small cell lung cancer cell, H1299, lines; Cyclamen extract induced cellular death of both HeLa and H1299 cells in a dose dependent manner. We also analyzed the capacity of cyclamen extract to induce apoptosis by the TUNEL method. Here, for the first time we report that the extract of Cyclamen coum, an endemic plant for Turkey, Bulgaria, Georgia and the Middle East can induce cytotoxicity via apoptosis in HeLa and H1299 cells. These results imply that cyclamen extract can be further analyzed to potentially find novel anticancer compounds.

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Section: Resultsmentioning

confidence: 99%

Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: a Step Toward New Anticancer Agents?

Yıldız¹,

Bozcu²,

Tokgün³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…This has led to the search of novel bioactive compounds and/or extracts against multiple myeloma from untapped resources. A plethora of successful anticancer drugs have been derived from natural plant products [28], and the search for new anticancer drugs from the plant kingdom is ongoing. In the same vein, we investigated the cytotoxic and apoptotic effect of non-edible parts of the Mauritian cultivar of pomegranate on U266 multiple myeloma cells.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells

et al. 2015

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Multiple myeloma is of great concern since existing therapies are unable to cure this clinical condition. Alternative therapeutic approaches are mandatory, and the use of plant extracts is considered interesting. Punica granatum and its derived products were suggested as potential anticancer agents due to the presence of bioactive compounds. Thus, polypenolic-rich extracts of the non-edible parts of P. granatum were investigated for their antiproliferative and apoptotic effects on U266 multiple myeloma cells. We demonstrated that there were dose-dependent decreases in the proliferation of U266 cells in response to P. granatum extracts. Also, exposure to the extracts triggered apoptosis with significant increases in loss of mitochondrial membrane potential in U266 cells exposed to the leaves and stem extracts, while the flower extract resulted in slight increases in loss of MMP. These results were confirmed by Annexin-V analysis. These results documented the cytotoxic and apoptotic effects of P. granatum extracts on human U266 multiple myeloma cells via disruption of mitochondrial membrane potential and increasing cell cycle arrest. The data suggest that the extracts can be envisaged in cancer chemoprevention and call for further exploration into the potential application of these plant parts.

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“…Unless otherwise noted, growth media and supplements were obtained from Cellgro. The collection and processing strategies for these understudied plant specimens from tropical rainforests has been recently reviewed (31). Briefly, a pilot sample (f20 g, dry weight) was extracted with a 9:1 methanol/water solution.…”

Section: Methodsmentioning

confidence: 99%

Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma–associated herpesvirus

Nun

Kroll

Oberlies

et al. 2007

Molecular Cancer Therapeutics

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Novel strategies for the discovery of plant-derived anticancer agents

Abstract: Abstract

Cited by 101 publications

References 0 publications

Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: a Step Toward New Anticancer Agents?

Cyclamen Exerts Cytotoxicity in Solid Tumor Cell Lines: a Step Toward New Anticancer Agents?

Apoptotic effects of non-edible parts of Punica granatum on human multiple myeloma cells

Development of a fluorescence-based assay to screen antiviral drugs against Kaposi's sarcoma–associated herpesvirus

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