Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Hoskin, Roberta Targino; Pambianchi, Erika; Pecorelli, Alessandra; Grace, Mary H.; Therrien, Jean Philippe; Valacchi, Giuseppe; Lila, Mary Ann

doi:10.3390/molecules26133781

Cited by 15 publications

(9 citation statements)

References 48 publications

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“…It was found that long-term supplementation improved all clinical–biochemical parameters monitored, including increased skin elasticity, reinforced skin barrier function and a reduction in wrinkle depth and black spots in the enrolled patients [ 45 ]. Hoskin et al demonstrated, for the first time, the effective action of the topical application of a gel based on hydroalcoholic rosemary extract complexed with algae proteins on pollution-induced oxidative skin damage [ 46 ]. The emerging molecular mechanisms through which rosemary phenolic diterpenes acts are the inhibition of the increasing levels of active metalloproteinase-9 (MMP-9), the reduction of protein adducts formation and the reduction of filaggrin loss, which are induced by dermal exposure to diesel engine exhausts (DEE).…”

Section: Resultsmentioning

confidence: 99%

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

et al. 2023

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The rosemary plant, Rosmarinus officinalis L., one of the main members of the Lamiaceae family, is currently one of the most promising herbal medicines due to its pharmaceutical properties. This research aimed to evaluate the antioxidant role of Rosmarinus officinalis and its bioactive compounds on the skin, with a focus on the newly emerging molecular mechanisms involved, providing extensive scientific evidence of its anti-inflammatory, antimicrobial, wound-healing and anticancer activity in dermatological practice. The search was conducted on articles concerning in vitro and in vivo studies in both animals and humans. The results obtained confirm the antioxidant role of R. officinalis. This assumption derives the possibility of using R. officinalis or its bioactive elements for the treatment of inflammatory and infectious skin pathologies. However, although the use of rosemary in the treatment of skin diseases represents a fascinating line of research, future perspectives still require large and controlled clinical trials in order to definitively elucidate the real impact of this plant and its components in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

et al. 2023

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“…Penetration of pollutants into skin is not completely elucidated yet either, but a recent study showed that topical diesel engine exhaust penetrated into the dermis and activated MMP-9 in ex vivo cultured human skin [ 36 ]. Thus, MMP-1 and MMP-3 could be activated in skin following exposure to DPE.…”

Section: Discussionmentioning

confidence: 99%

Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway

Shin

Uchida

Park

2022

IJMS

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Both intrinsic (i.e., an individual’s body clock) and extrinsic factors (i.e., air pollutants and ultraviolet irradiation) accelerate premature aging. Epidemiological studies have shown a correlation between pollutant levels and aging skin symptoms. Diesel particle matter in particular leads to some diseases, including in the skin. Our recent study demonstrates that diesel particulate extract (DPE) increases apoptosis via increases in an anti-mitogenic/pro-apoptotic lipid mediator, ceramide in epidermal keratinocytes. Here, we investigated whether and how DPE accelerates premature skin aging using cultured normal human dermal fibroblasts (HDF). We first demonstrated that DPE increases cell senescence marker β-galactosidase activity in HDF. We then found increases in mRNA and protein levels, along with activity of matrix metalloprotease (MMP)-1 and MMP-3, which are associated with skin aging following DPE exposure. We confirmed increases in collagen degradation in HDF treated with DPE. Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) is activated by DPE and results in increased ceramide production by sphingomyelinase activation in HDF. We identified that ceramide-1-phosphate (C1P) (produced from ceramide by ceramide kinase activation) activates MMP-1 and MMP-3 through activation of arachidonate cascade, followed by STAT 1- and STAT 3-dependent transcriptional activation.

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“…Established protocols previously reported by our team were used to produce spray‐dried protein–polyphenol particles (Grace et al., 2022; Hoskin et al., 2021, 2022). At least three independent batches of each treatment were prepared using a spray dryer B‐290 (Buchi Labortechnik) in co‐current flow and with previously optimized conditions: 0.7 mm nozzle, 10 mL/min of feed flow (controlled by peristaltic pump), and drying air inlet temperature of 160°C (defined in preliminary experiments, data not shown) and outlet temperature of 80–84°C.…”

Section: Methodsmentioning

confidence: 99%

“…The solids recovery of spray‐dried protein–polyphenol samples was calculated as percentage (%) according to the ratio [total solids content of resulting particles / total solids content in the feeding mixture (before spray drying)] × 100, according to our previous protocol (Hoskin et al., 2021). In addition, the percentage (%) total polyphenol (TP) retention was determined as the ratio [TP of spray dried powder, mg/g) × (solids in powder, g)] / (TP of feed mixture, mg/g) × (solids in feed mix, g) × 100 (Zhang et al., 2020).…”

Section: Methodsmentioning

confidence: 99%

Spray‐drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant‐based protein sources

Hoskin

Grace

Xiong

et al. 2023

Journal of Food Science

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The performance of buckwheat protein (BK) and chia seed protein (CP) as drying carriers for the microencapsulation of polyphenols extracted from blackcurrant pomace and cocoa powder was investigated. Four experimental groups were evaluated (BK–BC: blackcurrant pomace extract with buckwheat protein; CP–BC: blackcurrant pomace extract with chia:pea protein blend; BK–CC: cocoa extract with buckwheat protein; and CP–CC: cocoa extract with chia:pea protein blend) to determine physicochemical attributes, phytochemical content, antioxidant activity, and polyphenol in vitro bioaccessibility. Nonconventional, underexploited protein sources such as chia/pea protein blend and buckwheat protein efficiently produced functional microparticles with attractive color and texture, low hygroscopicity (<20% increase in moisture content when exposed to 86% relative humidity for 1 week), solubility above 50% at pH 7 and 10, and uniform particle size (29 < D4,3 < 56 µm). Besides this, the protein–polyphenol microparticles concentrated and protected health‐relevant polyphenol content. Anthocyanins were detected in blackcurrant treatments (around 20 mg cyanidin‐3‐O‐glucoside equivalents/g), while proanthocyanidins (PAC) were the most prevalent polyphenols in cocoa treatments (>100 mg PAC B2/g). Monomers were the main class of PAC in both BK–CC and CP–CC treatments. All protein–polyphenol treatments reduced both reactive oxygen species and nitric oxide production in lipopolysaccharide‐activated cells (p < 0.05). The polyphenol recovery index was high (>70%) for both oral and gastric phases, and BK‐derived groups had better bioaccessibility index compared to BC or CC alone (noncomplexed). This research provided a framework for delivery of high‐value ingredients to attend to an emerging market centered on protein‐rich, clean label plant‐based food products. Practical Application Practical Application: The protein–polyphenol complexation is a robust method to produce phytochemical‐rich food ingredients for the food industry with enhanced physicochemical, sensory, and bioaccessibility performance. In this study, we investigated practical aspects regarding the production and quality of protein–polyphenol particles, such as the spray‐drying efficiency, phytochemical content, physicochemical attributes, antioxidant activity, and polyphenol bioaccessibility. This study unveils the potential of underexplored buckwheat and chia seeds (alone or combined with pea protein) as encapsulation carriers for fruit polyphenols to diversify the protein options available for products directed to the wellness market.

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Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Cited by 15 publications

References 48 publications

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

Rosmarinus officinalis and Skin: Antioxidant Activity and Possible Therapeutical Role in Cutaneous Diseases

Diesel Particulate Extract Accelerates Premature Skin Aging in Human Fibroblasts via Ceramide-1-Phosphate-Mediated Signaling Pathway

Spray‐drying microencapsulation of blackcurrant and cocoa polyphenols using underexplored plant‐based protein sources

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