Novel spectroscopic methods for determination of Cromolyn sodium and Oxymetazoline hydrochloride in binary mixture

Abdelaziz, Omar Y.; El-Kosasy, Amira M.; Magdy, Nancy; Zahar, Noha M. El

doi:10.1016/j.saa.2014.04.047

Cited by 23 publications

(21 citation statements)

References 26 publications

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“…Consequently, spectrophotometric [4][5][6][7], high performance liquid chromatographic (HPLC) [8][9][10][11][12], chemiluminescence [13,14] and potentiometric methods [15] have been suggested for the determination of OXM. Some of the proposed spectrophotometric methods use either tedious lengthy calculations or they are highly dependent on the selection of the wavelength region which critically affects the precision and accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…Some of the proposed spectrophotometric methods use either tedious lengthy calculations or they are highly dependent on the selection of the wavelength region which critically affects the precision and accuracy. The other spectrophotometric method [5] is based on an oxidation reaction and suffers from a narrow linear range. On the other hand, the chromatographic methods are time and solvent consuming, while, the suggested chemiluminescence methods [13,14] require instrumentations with limited applications which make them not available in most laboratories for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

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All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

et al. 2019

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All-solid state potentiometric ion selective electrodes have the merits of being portable, small and suitable for small volume samples. Herein, disposable home-made screen printed polymeric ion selective electrode (SPE) is developed for determination of oxymetazoline (OXM) in pharmaceutical nasal drops and drug substance. Ion selective electrodes with optimal potentiometric response were achieved by careful selection of the ion exchanger and plasticizer. A screen printed electrode utilizing oxymetazoline-tetraphenyl borate (OXM-TPB) as an ion exchanger and dibutyl phthalate (DBP) as a plasticizer exhibited a Nernstian slope of 59.5±0.5 mV/decade (n=3) over the concentration range from 1×10-5 to 1×10-2 M OXM (r = 0.9999) with a detection limit of 5.0×10-6 M. The electrode is useful over a wide pH range from 4.0 to 8.0. The electrode showed a high selectivity for OXM against several common interfering ions. The potential interference from benzalkonium chloride was easily eliminated by treatment the sample with KI. Comparable potentiometric characteristics including linearity, detection limit, pH range and selectivity pattern were obtained with a carbon paste electrode (CPE) comprising same ion exchanger and plasticizer. The electrodes were successfully used for the assay of OXM in the drug substance and in the dosage form in presence of benzalkonium chloride with high accuracy (±2%) and precision (%RSD ˂2.5). The proposed method is simple, accurate and precise.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

et al. 2019

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“…Different analytical techniques were applied for quantitative estimation of oxymetazoline hydrochloride including spectrophotometric methods (3)(4)(5)(6)(7)(8), Chemiluminescence (9), TLC-densitometric (10), HPLC methods (10)(11)(12)(13)(14)(15) and electrochemical (potentiometric) method (16). 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole Figure 2 also known as 7-chloro-4-nitrobenzo-furazan (NBD-Cl) is a stable non-fluorescent pale-yellow solid (17).…”

Section: Introductionmentioning

confidence: 99%

Validated Spectrofluorimetric Method for The Determination of Oxymetazoline Hydrochloride via Derivatization with 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl)

Salama¹,

Abdel-Salam²,

Abdel-Halim³

et al. 2018

Eurasian J Anal Chem

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Objectives: An accurate and precise spectrofluorimetric method was developed and validated for the determination of non-selective adrenergic drug named; oxymetazoline hydrochloride (OMZ) in its pure form and nasal drops. Method: Based on nucleophilic substitution reaction of target drug with 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl) to form a highly fluorescent fluorophore with emission measured at 543 nm after excitation at 400 nm. Results: Under optimum conditions, the proposed method obeys Beer's law in the range of (1-12 µg mL-1) and the reaction mechanism was presented. Conclusion: The method was validated according to ICH guidelines for accuracy, precision and was successfully applied for the determination of the drug in its pure form and nasal drops. The obtained results were statistically compared with those of the reported method and found to be in good agreement.

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“…Several methods have been reported for the determination of SCG in pharmaceutical preparations such as spectrophotometry [3,4], electrophoresis [5], electrochemical [6,7] and HPLC methods [8][9][10][11][12][13][14]. OXMT has also been analyzed by several methods in pharmaceutical preparations such as spectrophotometry [3,[15][16][17][18][19][20][21][22][23], capillary electrophoresis [24,25], gas chromatography [26,27] and HPLC [28][29][30][31][32][33][34][35]. To the best of our knowledge, Abdel-Aziz et al [3] developed new accurate, sensitive and selective spectrophotometric and spectrofluorimetric methods for determination of SCG and OXMT.…”

Section: Introductionmentioning

confidence: 99%

“…OXMT has also been analyzed by several methods in pharmaceutical preparations such as spectrophotometry [3,[15][16][17][18][19][20][21][22][23], capillary electrophoresis [24,25], gas chromatography [26,27] and HPLC [28][29][30][31][32][33][34][35]. To the best of our knowledge, Abdel-Aziz et al [3] developed new accurate, sensitive and selective spectrophotometric and spectrofluorimetric methods for determination of SCG and OXMT. The aim of this study is to develop simple, accurate, precise and time saving spectrophotometric methods for the routine analysis of SCG and OXMT in quality control laboratories either in their pure forms or in pharmaceutical formulations with no prior separation.…”

Section: Introductionmentioning

confidence: 99%

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

et al. 2015

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Sodium cromoglycate (SCG) and oxymetazoline hydrochloride (OXMT) are administered in combination for effective treatment of nasal congestion and allergy. In this work, SCG was determined using direct spectrophotometry by measuring its zero order absorption spectra at its λmax 320.6 nm where OXMT showed zero absorbance. On the other hand, four simple, sensitive and precise spectrophotometric methods were developed and validated for the determination of OXMT in the presence of SCG in their laboratory prepared mixtures and pharmaceutical formulation, without preliminary separation; Method A: first derivative spectrophotometric method [ 1 D], Method B: first derivative of ratio spectra method [ 1 DD], Method C: ratio difference spectrophotometric method [RDSM] and Method D: ratio subtraction method [RSM]. Ratio manipulating methods (Method B, C and D) were done using divisor of 10.00 µg/mL SCG. Linear correlation was obtained in range 4-22 µg/mL for OXMT by methods A, B and D and 6-22 µg/mL for method C. All methods were validated in compliance with the International Conference on Harmonization (ICH) guidelines and satisfactory results were obtained. No significant difference was noted between the developed methods and the official one with respect to accuracy and precision.

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Novel spectroscopic methods for determination of Cromolyn sodium and Oxymetazoline hydrochloride in binary mixture

Cited by 23 publications

References 26 publications

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

All-solid-state polymeric screen printed and carbon paste ion selective electrodes for determination of oxymetazoline in pharmaceutical dosage forms

Validated Spectrofluorimetric Method for The Determination of Oxymetazoline Hydrochloride via Derivatization with 4-Chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl)

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

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