novel spectrophotometric method for the determination of mesalazine

Abstract

A sensitive, accurate and easy indirect spectrophotometric method was developed for the determination of mesalazine in its pure form and in pharmaceutical preparations (tablets, capsules). The method was based on the oxidation of the mixture of the drug compound with the hydralazine reagent by using the oxidizing agent potassium periodate in an acidic medium and in the presence of the surfactant triton (x-100), absorption was measured at 380 nm for the drug compound, and the molar absorbance of mesalazine was 1147.5 liters. Mol-1. cm-1. With a recovery rate of 99.38, the method was developed to be simple, inexpensive and fast because it does not include any solvent extraction. The method has been successfully applied to pharmaceutical preparations.