Abstract:This research evaluated the impact of novel somatostatin receptor subtype‐4 (SSTR4) agonist SM‐I‐26 on microglia inflammatory activation. SSTR4 shows particular promise as a treatment target for Alzheimer's disease (AD) given its microglia and neuronal localization in the brain. A hallmark of AD progression is microgliosis, associated with inflammatory activation. A SSTR4 agonist that lessens microglial inflammatory activity could help mitigate AD progression.The selective and high affinity SSTR4 agonist SM‐I‐… Show more
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