Novel solid-state fermentation extraction of 5-O-caffeoylquinic acid from heilong48 soybean using Lactobacillus helviticus: Parametric screening and optimization

Updating the status quo on the extraction of bioactive compounds in agro-products using a two-pot multivariate design. A comprehensive review

“…Chen et al 6 concluded that the Taguchi design and RSM (BBD) combinations could be applied to effectively screen and optimize the key variables that influenced the bioactives extracted from coffee leaves. To maximize 5-O-caffeoylquinic acid (5-CQA) extraction with improved antioxidants from soybean (heilong48, HS) under SSF, Akpabli-Tsigbe, et al 49 employed BBD. The ideal conditions (Table 4) resulted in a maximum 5-CQA (∼11.4 mg g −1 ), fermentation efficiency (∼30.5%), and antioxidant (∼46.1 mol AAE per g).…”

“…Their results indicated that negative pressure, extractant-to-sample ratio, and extraction time were crucial parameters for further optimization. PBD parametric screening of solid-state fermentation (SSF) extraction of 5- O -caffeoylquinic acid (5-CQA) from soybean was used by Akpabli-Tsigbe et al 49 Per their design matrix of time, temperature, inoculation size, pH, and sample to solvent ratio, they found out that incubation time, temperature, sample to solvent ratio, and pH were the important parameters influencing 5-CQA, antioxidants, and fermentation efficiency, based on the t -value of pH, solid–liquid ratio, temperature, and incubation time which were above the t -value limit line, thus showing that these four were the significant factors needed for further optimization. In research by Clodoveo et al 55 on the UAE of ripe Carobs’ polyphenols, a 7-factor and 2-level PBD was executed to examine the impact of extraction temperature, time, solvent concentration, liquid–solid ratio, sonication frequency, sonication power, and particle size on polyphenols recovery.…”

“…PBD, for example, has been used in various experiments. 18,23,[47][48][49][50][51][52] PBD was used in the ultrasonic extraction of samara oil and nervonic acid from Acer saccharum. 53 The PDB was used to screen seven variables (irradiation power, irradiation time, particle size, temperature, soaking time, liquid-solid ratio, and stirring rate) that could influence nervonic acid and samara oils' extraction yield.…”

Ultrasonic‐assisted extraction of bioactive chlorogenic acid from heilong48 soybean variety: Parametric optimization and evaluation of physicochemical and bioactive properties

“…Heilong48 soybean flour was prepared according to the method outlined in our previous works (Akpabli‐Tsigbe et al., 2021a, 2021b). Briefly, the HS variety was milled with a hammer crusher (FC160, Shanghai Traditional Chinese Medicine Machinery Factory, China) and further sieved (65‐inch, 0.25‐mm bore diameter; Shaoxing Shangyu Huafeng Hardware Instruments Co., Ltd., China) into fine flour with a particle size of 0.25 mm.…”

“…Heilong48 soybean flour was prepared according to the method outlined in our previous works (Akpabli-Tsigbe et al, 2021a, 2021b.…”