Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras

Esteves, Fábio; Raggi, Paolo; Folks, Russell; Keidar, Zohar; Askew, J. Wells; Rispler, Shmuel; O’Connor, Michael K.; Verdes, Liudmilla; Garcia, Ernest

doi:10.1007/s12350-009-9137-2

Cited by 246 publications

(165 citation statements)

References 13 publications

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“…Similar findings, indicating a diagnostic performance of the same dedicated cardiac camera comparable to that of a standard dual-detector SPECT on a per-patient basis with significantly shorter acquisition times, have been obtained by Esteves et al [10] in a multicentre trial designed to compare the two imaging systems in a group of 168 patients undergoing 1-day 99m Tc-tetrofosmin ECG-gated rest/stress (exercise, adenosine or dipyridamole) MPI. The same injected doses were used for performing all the images, with CZT acquisitions obtained immediately prior to conventional SPECT ones.…”

supporting

confidence: 80%

“…The system used in the above-mentioned three studies [8,10,11] is based on Alcyone technology (GE Healthcare), which combines focused pinhole collimation, an array of CZT pixilated detectors, 3-D reconstruction and stationary data acquisition. In this cardiac camera, the detectors and collimators do not move during image acquisition and all lines of response are acquired simultaneously through a proprietary multi-pinhole collimator.…”

mentioning

confidence: 99%

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Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Schillaci

Danieli

2010

Eur J Nucl Med Mol Imaging

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supporting

confidence: 80%

mentioning

confidence: 99%

Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Schillaci

Danieli

2010

Eur J Nucl Med Mol Imaging

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“…This technology is associated with higher sensitivity and better spatial and energy resolution compared to conventional MPS and its agreement with conventional MPS using a NaI-crystal technology has been clinically validated in several studies [3][4][5][6][7]. Furthermore, the CZT camera system enables complete 3D coverage and simultaneous image acquisition of the heart by using a stationary gantry with 19 pinhole collimators.…”

Section: Introductionmentioning

confidence: 93%

“…Thus, MPS is one of the procedures in diagnostic nuclear medicine that gives the highest effective dose contribution [11,12]. Instead of using the advantages with the CZT camera systems to perform fast myocardial perfusion imaging [3,[5][6][7], this technology could be used to reduce the administered activity to decrease the effective dose to the patient. One previous study [13] indicates that reduced activity could be used but further validation is needed.…”

Section: Introductionmentioning

confidence: 99%

Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera

Oddstig

Hedeer

Jögi

et al. 2013

Journal of Nuclear Cardiology

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Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera. Link to publication Citation for published version (APA): Oddstig, J., Hedeer, F., Jögi, J., Carlsson, M., Hindorf, C., & Engblom, H. (2013). Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera. Journal of Nuclear Cardiology, 20(1), 38-44. DOI: 10.1007/s12350-012-9634-6 General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal Abstract BackgroundFor a 1-day myocardial perfusion SPECT (MPS) the recommendations for administered activity stated in the EANM guidelines results in an effective dose of up to 16 mSv per patient. Recently, a gamma camera system, based on cadmium zinc telluride (CZT) technology, was introduced. This technique has the potential to reduce the effective dose and scan time compared to the conventional NaI gamma camera. The aim of this study was to investigate if the effective dose can be reduced with a preserved image quality using CZT-technology in MPS. MethodsIn total, 150 patients were included in the study. All underwent a 1-day 99m Tc-tetrofosmin stress-rest protocol and were divided into three subgroups (n=50 in each group) with 4 MBq/kg, 3 MBq/kg and 2.5 MBq/kg body weight of administered activity in the stress examination, respectively. The acquisition time was increased in proportion to the decrease in administered activity. All examinations were analysed for image quality by visual grading on a 4-point scale (1 = poor, 2 = adequate, 3 = good, 4 = excellent), by two expert readers. ResultsThe total effective dose (stress + rest) decreased from 9.3 mSv to 5.8 mSv comparing 4 MBq/kg to 2.5 MBq/kg body weight. For the patients undergoing stress examination only (35%) the effective dose, administrating 2.5 MBq/kg, was 1.4 mSv. The image acquisition times for 2.5 MBq/kg body weight were 475 s and 300 s (stress and rest) compared to 900 s for each when using conventional MPS. The average image quality was 3.7±0.5, 3.8±0.5 and 3.8±0.4 for the stress images and 3.5±0.6, 3.6±0.6 and 3.5±0.6 for the rest images and showed no statistically significant difference (p=0.62) between the 4 MBq/kg, 3 MBq/kg and 2.5 MBq/kg groups. ConclusionsThe new CZT technology can be used to considerably decrease the effective dose and acquisition time for MPS with preserved high image quality. KeywordsMyocardial perfusion imaging, SPECT, CZT detector, effective dose, image quality 2 Background Myocardial p...

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“…Also early clinical validation studies have appeared recently [4,5]. The described system (available from GE Healthcare) joins a range of novel organ-specific commercial systems that have recently been introduced to the consumer with reported improvement in resolution and sensitivity (usually reported as potential for reduced acquisition time; see recent reviews [6,7]). Specific examples are the D-SPECT from Spectrum Dynamics [8,9] and the Cardius from Digirad [10].…”

Section: Major Advances In Organ-specific Imagingmentioning

confidence: 99%

New SPECT technology: potential and challenges

Hutton

2010

Eur J Nucl Med Mol Imaging

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Potential Major advances in organ-specific imagingThe article by Bocher et al. in this issue [1] reports on the performance of a novel SPECT system specifically designed for cardiac imaging based on the use of a set of pinhole collimators in combination with cadmium zinc telluride (CZT) detectors. The system is inspired by earlier work on multipinhole imaging [2] and the conceptual design has previously been demonstrated in simulation studies [3]. Also early clinical validation studies have appeared recently [4,5]. The described system (available from GE Healthcare) joins a range of novel organ-specific commercial systems that have recently been introduced to the consumer with reported improvement in resolution and sensitivity (usually reported as potential for reduced acquisition time; see recent reviews [6,7]). Specific examples are the D-SPECT from Spectrum Dynamics [8,9] and the Cardius from Digirad [10]. Clinical validation studies for these systems are now also appearing (e.g. [11,12]). The developers of these systems deserve congratulations for introducing innovations that undoubtedly yield the largest advance in SPECT performance since the introduction of the rotating gamma camera, which has dominated clinical use for several decades. Until recently the development in SPECT performance has been incremental, mainly involving refinement rather than major changes in system design, perhaps mainly due to the clinical demand for systems that offer flexibility in application. The recent innovation has been inspired at least partly by the rapid developments in preclinical imaging systems where ultrahigh resolution and relatively high sensitivity have been demonstrated. Bringing new designs to fruition has only been possible due to the combination of several factors: the improved reliability of alternative detector materials, the development of fast electronics, the development of efficient reconstruction algorithms and, not least, the demand for organ-specific systems where optimization for a specific purpose rather than flexibility in application is indicated. CZT: pros and consCentral to the design of both the GE Healthcare system and the D-SPECT is the use of CZT. Although not a new detector material, it is only recently that the reliability and performance of CZT at room temperature have been sufficiently improved to make clinical use a possibility. The cost of CZT remains relatively high and places a constraint on the possible designs. But the appeal is not just the much improved energy resolution (typically 5-6%) but particularly the small size that facilitates novel compact designs, which are very much appealing for use in organspecific imaging. There are alternative approaches to achieving compact designs based on conventional scintillation detectors coupled to optical readout systems other than conventional photomultiplier tubes (e.g. avalanche photodiode or silicon photomultiplier), which may have a cost advantage (see [13] for a useful overview). We can anticipate increasing use of new technology in f...

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Novel solid-state-detector dedicated cardiac camera for fast myocardial perfusion imaging: multicenter comparison with standard dual detector cameras

Cited by 246 publications

References 13 publications

Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Dedicated cardiac cameras: a new option for nuclear myocardial perfusion imaging

Reduced administered activity, reduced acquisition time, and preserved image quality for the new CZT camera

New SPECT technology: potential and challenges

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