Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins

Zhao, Zihan; Wang, C.F.; Li, Q.L.; Zhong, Ju; Huang, J.M.; Li, J.B.; Zhong, Juming; Zhang, J.B.

doi:10.4238/2012.october.15.6

Cited by 14 publications

(4 citation statements)

References 32 publications

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“…Further, Zhao et al . [ 57 ] with correlation analysis showed that the g.1197 C>A marker was significantly correlated to SCS, and the g.1164 G>A locus had significant effects on SCS, suggesting possible roles of these SNPs in the host response against mastitis in Chinese Holsteins.…”

Section: Immuno-pathogenesismentioning

confidence: 99%

Molecular markers for resistance against infectious diseases of economic importance

et al. 2017

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Huge livestock population of India is under threat by a large number of endemic infectious (bacterial, viral, and parasitic) diseases. These diseases are associated with high rates of morbidity and mortality, particularly in exotic and crossbred cattle. Beside morbidity and mortality, economic losses by these diseases occur through reduced fertility, production losses, etc. Some of the major infectious diseases which have great economic impact on Indian dairy industries are tuberculosis (TB), Johne’s disease (JD), mastitis, tick and tick-borne diseases (TTBDs), foot and mouth disease, etc. The development of effective strategies for the assessment and control of infectious diseases requires a better understanding of pathogen biology, host immune response, and diseases pathogenesis as well as the identification of the associated biomarkers. Indigenous cattle (Bos indicus) are reported to be comparatively less affected than exotic and crossbred cattle. However, genetic basis of resistance in indigenous cattle is not well documented. The association studies of few of the genes associated with various diseases, namely, solute carrier family 11 member 1, Toll-like receptors 1, with TB; Caspase associated recruitment domain 15, SP110 with JD; CACNA2D1, CD14 with mastitis and interferon gamma, BoLA-DRB3.2 alleles with TTBDs, etc., are presented. Breeding for genetic resistance is one of the promising ways to control the infectious diseases. High host resistance is the most important method for controlling such diseases, but till today no breed is total immune. Therefore, work may be undertaken under the hypothesis that the different susceptibility to these diseases are exhibited by indigenous and crossbred cattle is due to breed-specific differences in the dealing of infected cells with other immune cells, which ultimately influence the immune response responded against infections. Achieving maximum resistance to these diseases is the ultimate goal, is technically possible to achieve, and is permanent. Progress could be enhanced through introgression of resistance genes to breeds with low resistance. The quest for knowledge of the genetic basis for infectious diseases in indigenous livestock is strongly warranted.

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Section: Immuno-pathogenesismentioning

confidence: 99%

Molecular markers for resistance against infectious diseases of economic importance

et al. 2017

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“…In the same line, The substantial correlation between SNPs in the MBL and milk somatic cell score (SCS), a significant phenotypic marker of bovine mastitis, has also been noted by other research studies [48,49]. In Chinese Holstein cattle, the genetic variants of the TRAPPC9 and C4A genes were proven to be associated with mastitis resistance [50,51].…”

Section: Mastitis Susceptibility With Immune and Antioxidant Gene Pol...mentioning

confidence: 66%

Combining Nucleotide Sequence Variants and Transcript Levels of Immune and Antioxidant Markers for Selection and Improvement of Mastitis Resistance in Dromedary Camels

Ateya,

Safhi,

El-Emam

et al. 2023

Agriculture

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The immune and antioxidant genetic factors that could converse with mastitis susceptibility in dromedary camels were looked at in this research. Of 120 female dromedary camels (60 healthy, and 60 with mastitis) were utilised. Each camel’s jugular vein was pierced to obtain five millilitres of blood. The blood was placed within tubes containing sodium fluoride or EDTA anticoagulants to obtain whole blood and extract DNA and RNA. The immunological (OTUD3, TLR2, TLR4, STAB2, MBL2, TRAPPC9, and C4A) and antioxidant (CAT, SOD3, PRDX6, OXSR1, NDUFS6, SERP2, and ST1P1) genes’ nucleotide sequence polymorphisms between healthy and mastitis affected she-camels were discovered using PCR-DNA sequencing. Fisher’s exact test revealed that camel groups with and without mastitis had noticeably different odds of all major nucleotide alterations propagating (p < 0.01). Mastitic camels were significantly more likely to express the OTUD3, TLR2, TLR4, STAB2, MBL2, TRAPPC9, C4A, OXSR1, SERP2, and ST1P1 genes (p < 0.05). However, CAT, SOD3, PRDX6, and NDUFS6 genes elicited a different pattern. The results may be used to develop management strategies and support the significance of nucleotide differences and gene expression patterns in these markers as indicators of the incidence of mastitis.

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“…Many studies have indicated the association of SNPs of lectin pathway in the complement genes with different responses to mastitis resistance. For instance, the mutations in the mannan binding lectin 1, mannan binding lectin 2 and complement C4 genes have been associated with mastitis resistance in the Chinese Holstein cattle [4,20,21]. Moreover, MASP2 is another central protease of the lectin pathway.…”

Section: Single Nucleotide Polymorphism Of Masp2mentioning

confidence: 99%

Polymorphisms of MASP2 gene and its relationship with mastitis and milk production in Chinese Holstein cattle

Zhang

Yan

Zhang

et al. 2019

Biotechnology & Biotechnological Equipment

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Mastitis is a deleterious disease of dairy cattle, and its incidence is closely related with the innate immune response, including the complement system. Mannose-binding lectin-associated serine protease 2 (MASP2) is a functional central enzyme in the complement system. Here, we aimed to study single nucleotide polymorphisms (SNPs) of MASP2 and its relationship with mastitis and milk production in Chinese Holstein cattle. We found three novel SNPs, namely g.14047A > C, g.14248T > C and g.14391C > T, in MASP2. The SNP g.14047 A > C (GAA (Glu)>GAC (Asp)) at position 608aa of MASP2 was correlated with the CH50 level and the protein percentage. Meanwhile, the SNP g.14248 T > C (ATT (Ile) > ATC (Ile)) at position 675aa was also correlated with the CH50 value and the milk production. The haplotype combinations H2H2 and H2H4 showed a significant relationship with the CH50, SCS and the milk production abilities, respectively. Based on the SNPs identified in this gene, several genotypes and haplotypes, respectively, were found in Chinese Holstein cattle. The genotypes AC (g.14047 A > C) and TT (g.14248 T > C) and the haplotype combinations H2H2 and H2H4 may be used as molecular markers for breeding mastitis-resistant dairy cattle. The haplotype combination H1H2 should be gradually phased out in breeding programmes.

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Novel SNPs of the mannan-binding lectin 2 gene and their association with production traits in Chinese Holsteins

Cited by 14 publications

References 32 publications

Molecular markers for resistance against infectious diseases of economic importance

Molecular markers for resistance against infectious diseases of economic importance

Combining Nucleotide Sequence Variants and Transcript Levels of Immune and Antioxidant Markers for Selection and Improvement of Mastitis Resistance in Dromedary Camels

Polymorphisms of MASP2 gene and its relationship with mastitis and milk production in Chinese Holstein cattle

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