Novel SNPs of the Caprine Growth Hormone Secretagogue Receptor (GHSR) Gene and Their Association with Growth Traits in Goats

Jin, Qijiang; Fang, Xinggen; Yang, Liu; Zhang, Chun Lei; Sun, Jian; Chen, Dan Xia; Shi, Xinying; Du, Yong‐Zhong; Lei, C. Z.; Chen, Hong

doi:10.1007/s10528-010-9366-8

Cited by 6 publications

(4 citation statements)

References 12 publications

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“…where, Y ijk is a record of individual phenotype value; U is the group average; marker k is a marker gene type effect; E ijk is a random error (Jin et al, 2010;Yuan et al, 2010;Liu et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Molecular cloning, polymorphisms, and expression analysis of the RERG gene in indigenous Chinese goats

Sui

Wang

2015

Genet. Mol. Res.

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ABSTRACT. The current study aimed to investigate the coding sequence, polymorphisms, and expression of the RERG gene in indigenous Chinese goats. cDNA of RERG, obtained through reverse transcription PCR was analyzed using bioinformatic techniques. Polymorphisms in the exon regions of the RERG gene were identified and their associations with growth traits in three varieties of indigenous Chinese goats were investigated. Expression of the RERG gene in three goat breeds of the same age was detected using real-time quantitative PCR. The results revealed that the cDNA of RERG, which contained a complete open reading frame of 20-620 bp, was 629 bp in length. The associated accession numbers in GenBank are JN672576, JQ917222, and JN580309 for the QianBei Ma goat, the GuiZhou white goat, and the GuiZhou black goat, respectively. Four consistent SNP sites were found in the exon regions of the RERG gene for the three goat breeds. mRNA expression of the RERG gene differed between different tissues in adult goats of same age. The highest expression was observed in lung

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Section: Discussionmentioning

confidence: 99%

Molecular cloning, polymorphisms, and expression analysis of the RERG gene in indigenous Chinese goats

Sui

Wang

2015

Genet. Mol. Res.

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“…In a study aimed at identifying genetic polymorphisms, which could serve as predictive markers of response to rhGH therapy, no such marker in GHSR was found [140]. In contrast, body length and weight of goats and pigs were significantly higher in animals carrying a GHSR polymorphism [141, 142].…”

Section: Genetic Conditions Associated With Normal Gh Sensitivitymentioning

confidence: 99%

Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion

et al. 2021

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The current differential diagnosis for a short child with low insulin-like growth factor I (IGF-I) and a normal growth hormone (GH) peak in a GH stimulation test (GHST), after exclusion of acquired causes, includes the following disorders: (1) a decreased spontaneous GH secretion in contrast to a normal stimulated GH peak (“GH neurosecretory dysfunction,” GHND) and (2) genetic conditions with a normal GH sensitivity (e.g., pathogenic variants of GH1 or GHSR) and (3) GH insensitivity (GHI). We present a critical appraisal of the concept of GHND and the role of 12- or 24-h GH profiles in the selection of children for GH treatment. The mean 24-h GH concentration in healthy children overlaps with that in those with GH deficiency, indicating that the previously proposed cutoff limit (3.0–3.2 μg/L) is too high. The main advantage of performing a GH profile is that it prevents about 20% of false-positive test results of the GHST, while it also detects a low spontaneous GH secretion in children who would be considered GH sufficient based on a stimulation test. However, due to a considerable burden for patients and the health budget, GH profiles are only used in few centres. Regarding genetic causes, there is good evidence of the existence of Kowarski syndrome (due to GH1 variants) but less on the role of GHSR variants. Several genetic causes of (partial) GHI are known (GHR, STAT5B, STAT3, IGF1, IGFALS defects, and Noonan and 3M syndromes), some responding positively to GH therapy. In the final section, we speculate on hypothetical causes.

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“…In goats, association studies have revealed the existence of relationships between GH genotype and a wide array of growth parameters such as body length and height [63,64], and birth chest and weaning weight and height [65]. Similarly, the variability of the GH receptor has been associated with body length and height [65], while the growth hormone secretagogue receptor genotype displays significant associations with body length and body length index [66]. Myostatin (MSTN) belongs to the transforming growth factor-(TGF-) superfamily and it has been shown to repress muscular growth [67].…”

Section: Candidate Genes For Growth and Meat Quality Traitsmentioning

confidence: 99%

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

Amills

2014

Advances in Biology

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Goat genomics has evolved at a low pace because of a lack of molecular tools and sufficient investment. Whilst thousands and hundreds of quantitative trait loci (QTL) have been identified in cattle and sheep, respectively, about nine genome scans have been performed in goats dealing with traits as conformation, growth, fiber quality, resistance to nematodes, and milk yield and composition. In contrast, a great effort has been devoted to the characterization of candidate genes and their association with milk, meat, and reproduction phenotypes. In this regard, causal mutations have been identified in the S1 -casein gene that has a strong effect on milk composition and the PIS locus that is linked to intersexuality and polledness. In recent times, the development of massive parallel sequencing technologies has allowed to build a reference genome for goats as well as to monitor the expression of mRNAs and microRNAs in a broad array of tissues and experimental conditions. Besides, the recent design of a 52K SNP chip is expected to have a broad impact in the analysis of the genetic architecture of traits of economic interest as well as in the study of the population structure of goats at a worldwide scale.

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Novel SNPs of the Caprine Growth Hormone Secretagogue Receptor (GHSR) Gene and Their Association with Growth Traits in Goats

Cited by 6 publications

References 12 publications

Molecular cloning, polymorphisms, and expression analysis of the RERG gene in indigenous Chinese goats

Molecular cloning, polymorphisms, and expression analysis of the RERG gene in indigenous Chinese goats

Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion

The Application of Genomic Technologies to Investigate the Inheritance of Economically Important Traits in Goats

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